Zobrazeno 1 - 10
of 15 094
pro vyhledávání: '"L Boyle"'
Autor:
Samuel Schwab, Yimin Hu, Bert van Erp, Marc K. M. Cajili, Marcus D. Hartmann, Birte Hernandez Alvarez, Vikram Alva, Aimee L. Boyle, Remus T. Dame
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Histones are important chromatin-organizing proteins in eukaryotes and archaea. They form superhelical structures around which DNA is wrapped. Recent studies have shown that some archaea and bacteria contain alternative histones that exhibit
Externí odkaz:
https://doaj.org/article/ee1726d5e7934d70aae55b1a914800b2
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Publikováno v:
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XLVIII-2-2024, Pp 41-48 (2024)
The term speech sound disorder describes a range of speech difficulties in children that affect speech intelligibility. Differential diagnosis is difficult and reliant on access to validated and reliable measures. Technological advances aim to provid
Externí odkaz:
https://doaj.org/article/14adfd9cd9bf4eefa9a182d4c4dad98e
Publikováno v:
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Vol XLVIII-2-2024, Pp 121-128 (2024)
Corals are critical reef-building organisms, providing essential habitat and ecosystem services. Tracking coral growth over time indicates coral reef health, which can be measured using various established techniques. Several coral growth-related stu
Externí odkaz:
https://doaj.org/article/d483c6981af54e219b7798a0002fcaa7
Autor:
Eddie A. James, V. Michael Holers, Radhika Iyer, E. Barton Prideaux, Navin L. Rao, Cliff Rims, Virginia S. Muir, Sylvia E. Posso, Michelle S. Bloom, Amin Zia, Serra E. Elliott, Julia Z. Adamska, Rizi Ai, R. Camille Brewer, Jennifer A. Seifert, LauraKay Moss, Saman Barzideh, M. Kristen Demoruelle, Christopher C. Striebich, Yuko Okamoto, Enkhtsogt Sainbayar, Alexandra A. Crook, Ryan A. Peterson, Lauren A. Vanderlinden, Wei Wang, David L. Boyle, William H. Robinson, Jane H. Buckner, Gary S. Firestein, Kevin D. Deane
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here
Externí odkaz:
https://doaj.org/article/a3d2e67207bd4673ae2092ef39c22e10
Autor:
S.J. Hendriks, E. Santillan-Urquiza, A. Valldecabres, A.S. Hancock, L. Dalton, L. Boyle, B. O'Brien
Publikováno v:
Animal, Vol 18, Iss 3, Pp 101095- (2024)
Milk markers have the potential to aid in the detection of cow disease in early lactation if the automation of milk analysis becomes commonplace. Characterising temporal profiles of milk markers in dairy cows will improve the understanding of basal c
Externí odkaz:
https://doaj.org/article/300cf226ad404e798788fe86b8d15c22
Publikováno v:
Ecological Indicators, Vol 158, Iss , Pp 111510- (2024)
Governments and society increasingly are demanding that industrial projects result in a net positive impact (NPI) on biodiversity. Impacts are commonly measured in terms of losses and gains of area and quality of vegetation, where quality refers to h
Externí odkaz:
https://doaj.org/article/f3b3b5cf2a704d6f8d3386f331123f15
Autor:
Hyeonjeong Lee, Camilla R L Machado, Deepa Hammaker, Eunice Choi, Edward B Prideaux, Wei Wang, David L Boyle, Gary S Firestein
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304530 (2024)
Rheumatoid arthritis (RA) is a systemic immune-mediated disease characterized by joint inflammation and destruction. The disease typically affects small joints in the hands and feet, later progressing to involve larger joints such as the knees, shoul
Externí odkaz:
https://doaj.org/article/2b85a7c05bcd4e318c6f0ff23d6ac2bb
Autor:
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology. Here the authors use a Taiji computational approach to analyze gene expr
Externí odkaz:
https://doaj.org/article/c8daa11cab114d9a8d1dd398242e20b7
Autor:
Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nieman, Steven E. McKenzie, Christian Con Yost, Leslie A. Lange, Mary Cushman, Marguerite R. Irvin, Paul F. Bray, Robert A. Campbell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, an
Externí odkaz:
https://doaj.org/article/d092af6b93764c9897fa3db88dadf434