Zobrazeno 1 - 10
of 46
pro vyhledávání: '"L Baecher-Steppan"'
Publikováno v:
The Journal of Immunology. 157:2310-2319
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a widespread environmental contaminant and prototypic ligand for the aryl hydrocarbon receptor, is a potent immunotoxicant. To understand the underlying mechanisms of TCDD immunotoxicity, we have characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9127df8db144e33bcf406e774f4644dc
https://doi.org/10.4049/jimmunol.157.6.2310
https://doi.org/10.4049/jimmunol.157.6.2310
Publikováno v:
Fundamental and Applied Toxicology. 14:523-531
Lipid partitioning of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inadequately explains its tissue distribution since higher concentrations occur in liver than fat except at high doses. This study provides in vivo evidence that an inducible, saturable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22460c2e4200e472cae7c96d6da7aa4e
https://doi.org/10.1016/0272-0590(90)90256-j
https://doi.org/10.1016/0272-0590(90)90256-j
Autor:
L Baecher-Steppan, B B Smith, M C Henderson, Donald R. Buhler, Nancy I. Kerkvliet, J A Youngberg
Publikováno v:
Toxicological Sciences. 14:532-541
Previous studies have shown that the generation of cytotoxic T lymphocytes (CTL) following allogeneic tumor challenge is suppressed in Ah-responsive C57Bl/6 mice treated with a single oral dose of the toxic, Ah receptor-binding 3,4,5,3',4',5'-hexachl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c42a4aaa2bd03124d8c41939661cc1
https://doi.org/10.1093/toxsci/14.3.532
https://doi.org/10.1093/toxsci/14.3.532
Publikováno v:
Toxicology and applied pharmacology. 185(2)
The cellular basis for the potent suppression of T cell-mediated immune responses in mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is not fully understood. Although activation of the aryl hydrocarbon receptor (AhR) is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4774cc03b6097830a6d7cf242a3af6e2
https://pubmed.ncbi.nlm.nih.gov/12490139
https://pubmed.ncbi.nlm.nih.gov/12490139
Publikováno v:
Toxicology letters. 74(3)
Prostaglandin-E2 (PGE2) was investigated for its role in suppression of splenic cytotoxic T lymphocyte (CTL) activity following exposure to 3,3′,4,4′,5,5′-hexachlorobiphenyl (HxCB) in mice. Following i.p. alloantigen injection, PGE2 levels sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048f07d18ceb3c6f8728c942701e4dc0
https://pubmed.ncbi.nlm.nih.gov/7871545
https://pubmed.ncbi.nlm.nih.gov/7871545
Publikováno v:
Toxicology. 86(1-2)
Polybrominated diphenyl ethers are manufactured for use as flame retardants in commercial plastics and textiles in Europe and North America. These studies investigated the acute and subchronic immunotoxicity and endocrine effects of a commercial pent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0943d660a3f53cc9b4c5370dc654839c
https://pubmed.ncbi.nlm.nih.gov/8134923
https://pubmed.ncbi.nlm.nih.gov/8134923
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(1)
The cytotoxic T lymphocyte (CTL) response to allogeneic P815 tumor in C57bl/6 mice is dose-dependently suppressed after treatment with 3,3',4,4',5,5'-hexachlorobiphenyl (HxCB). Elevation of plasma corticosterone (CS) is also observed coincident with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d0110b5c785d7b8671ae2602e8a9b89
https://pubmed.ncbi.nlm.nih.gov/8229756
https://pubmed.ncbi.nlm.nih.gov/8229756
Publikováno v:
International Journal of Immunopharmacology. 7:239-247
The effects of technical grade pentachlorophenol (T-PCP) exposure on several immunological parameters were examined in adult C57B1/6 mice following eight weeks of dietary exposure. Immune function tests included mitogen-induced lymphocyte blastogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f644411c88e67a371253b3c5bd74286
https://doi.org/10.1016/0192-0561(85)90032-3
https://doi.org/10.1016/0192-0561(85)90032-3
Publikováno v:
Fundamental and Applied Toxicology. 12:773-786
The broiler chicken was developed as an alternative animal model to laboratory rodents for immunotoxicologic assessment. In vivo treatment with 100–200 mg/kg cyclophosphamide (CY) was used as a known immunosuppressive treatment to standardize the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a7c7a4c48a60f049ded02b11e286e57
https://doi.org/10.1016/0272-0590(89)90009-2
https://doi.org/10.1016/0272-0590(89)90009-2
Publikováno v:
Toxicology and Applied Pharmacology. 62:55-64
Adult male C57B16 mice were fed diets containing 50 or 500 ppm pure (99+%) or technical grade (86%) pentachlorophenol (PCP) for 10–12 weeks prior to assessment of immunocompetence. Assays for immunocompetence included in vivo host susceptibility to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834c422b7387c559a51d9561cbf3111b
https://doi.org/10.1016/0041-008x(82)90101-6
https://doi.org/10.1016/0041-008x(82)90101-6