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Autor:
Tetiana Taran, Y-S Yap, Anne C Armstrong, Francis P. Arena, Mustafa Ozguroglu, B H Xu, Kunwei Shen, Claudine Isaacs, Zsuzsanna Papai, Ruth O'Regan, Guillermo Lerzo, L B Pacaud, A Jappe, István Láng, Noriyuki Masuda, Michelle White, Yunyu Zhang
Publikováno v:
Cancer Research. 76:P4-13
Background PI3K/AKT/mTOR pathway activation due to PTEN loss may lead to trastuzumab (TRAS) resistance. mTOR inhibition has been shown to restore TRAS sensitivity in PTEN-deficient tumors. This provided the rationale for the BOLERO-3 trial which eval