Zobrazeno 1 - 8 of 8 pro vyhledávání: '"L B Angus"'
1
Protein engineering of novel plasminogen activators with increased thrombolytic potency in rabbits relative to activase
Autor: G A Timony, Glenn R. Larsen, K S Henson, J B Stoudemire, P G Horgan, K M Barone, L B Angus
Publikováno v: Journal of Biological Chemistry. 266:8156-8161
Human tissue-type plasminogen activator (t-PA) is a glycoprotein used currently in thrombolytic therapy for patients with acute myocardial infarction. Due to its rapid rate of clearance from the circulation, continuous intravenous administration of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2475c0babdb575e780a7ebe01126aade
https://doi.org/10.1016/s0021-9258(18)92955-8
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2
Replacement of finger and growth factor domains of tissue plasminogen activator with plasminogen kringle 1. Biochemical and pharmacological characterization of a novel chimera containing a high affinity fibrin-binding domain linked to a heterologous protein
Autor: L B Angus, Glenn R. Larsen, G E Morris, K M Barone, P G Horgan, Ahern Tim J, G A Timony, J B Stoudemire, M J Brenner, P R Langer-Safer
Publikováno v: Journal of Biological Chemistry. 266:3715-3723
A novel triple-kringle plasminogen activator protein, PK1 delta FE1X, has been produced which is a genetic chimera between the fibrin binding kringle 1 domain of plasminogen and the two kringles and serine protease domains of naturally occurring wild
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98115804d76878514ed49243b3cf5a94
https://doi.org/10.1016/s0021-9258(19)67853-1
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3
Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation
Autor: L B Angus, J B Stoudemire, Ahern Tim J, G A Timony, G E Morris, K S Henson, P G Horgan, K M Barone, P R Langer-Safer, Glenn R. Larsen
Publikováno v: Journal of Biological Chemistry. 265:5540-5545
Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eba31d8307d684ad1449c473dc2a798d
https://doi.org/10.1016/s0021-9258(19)39394-9
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4
Protein engineering of novel plasminogen activators with increased thrombolytic potency in rabbits relative to activase
Autor: G R, Larsen, G A, Timony, P G, Horgan, K M, Barone, K S, Henson, L B, Angus, J B, Stoudemire
Publikováno v: The Journal of biological chemistry. 266(13)
Human tissue-type plasminogen activator (t-PA) is a glycoprotein used currently in thrombolytic therapy for patients with acute myocardial infarction. Due to its rapid rate of clearance from the circulation, continuous intravenous administration of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0cf739790706c067bf6f81ac9069ea1
https://pubmed.ncbi.nlm.nih.gov/1708773
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5
Replacement of finger and growth factor domains of tissue plasminogen activator with plasminogen kringle 1. Biochemical and pharmacological characterization of a novel chimera containing a high affinity fibrin-binding domain linked to a heterologous protein
Autor: P R, Langer-Safer, T J, Ahern, L B, Angus, K M, Barone, M J, Brenner, P G, Horgan, G E, Morris, J B, Stoudemire, G A, Timony, G R, Larsen
Publikováno v: The Journal of biological chemistry. 266(6)
A novel triple-kringle plasminogen activator protein, PK1 delta FE1X, has been produced which is a genetic chimera between the fibrin binding kringle 1 domain of plasminogen and the two kringles and serine protease domains of naturally occurring wild
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ed8a81927d955f666f56d9e573aea19
https://pubmed.ncbi.nlm.nih.gov/1847387
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6
Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation
Autor: T J, Ahern, G E, Morris, K M, Barone, P G, Horgan, G A, Timony, L B, Angus, K S, Henson, J B, Stoudemire, P R, Langer-Safer, G R, Larsen
Publikováno v: The Journal of biological chemistry. 265(10)
Recombinant variants of tissue plasminogen activator (t-PA) containing either substitutions or deletions of amino acids within the fibronectin finger-like domain (residues 6-50) were found to exhibit widely varying in vivo clearance profiles in rats
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::449dc56bdfee8ee11724a1009bd4efe5
https://pubmed.ncbi.nlm.nih.gov/2108143
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7
Double Loop Receiver Coil for MR Imaging at 0.15 T
Autor: Jeffrey R. Fitzsimmons, Anthony A. Mancuso, L B Angus, M Boucher, E W Akins
Publikováno v: Journal of Computer Assisted Tomography. 10:1083-1088
A receiver coil of a cross-coupled, double loop geometry has been developed. This coil has a higher signal-to-noise (S/N) ratio and more homogeneous signal intensity at increasing depth than a conventional surface coil. Improvements in S/N of 51-256%
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f609c53b30f3b6a8b906e31686a0aa1
https://doi.org/10.1097/00004728-198611000-00047
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