Zobrazeno 1 - 10
of 26
pro vyhledávání: '"L B, Shih"'
Autor:
R, Stein, S V, Govindan, M J, Mattes, L B, Shih, G L, Griffiths, H J, Hansen, D M, Goldenberg
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
A new nonmetabolizable peptide approach to the production of residualizing radioiodine was evaluated in nude mice bearing xenografts of human lung adenocarcinoma (Calu-3) and B-cell lymphoma (Ramos). Monoclonal antibodies (MAbs) RS7 (anti-epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::199e9172816a0370eb3bf45fded242c4
https://pubmed.ncbi.nlm.nih.gov/10541347
https://pubmed.ncbi.nlm.nih.gov/10541347
Autor:
S O, Leung, Z, Qu, H J, Hansen, L B, Shih, J, Wang, M J, Losman, D M, Goldenberg, R M, Sharkey
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5
Antibody (Ab) fragments are preferred agents for imaging applications because of their rapid clearance from the blood, thereby providing high tumor:blood ratios within a few hours. Several preclinical studies have also suggested that Ab fragments mig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::679dbf9a61a89c208d0f8c3e8d6718e9
https://pubmed.ncbi.nlm.nih.gov/10541351
https://pubmed.ncbi.nlm.nih.gov/10541351
Autor:
M J, Losman, H J, Hansen, H, Dworak, I S, Krishnan, Z, Qu, L B, Shih, L, Zeng, D M, Goldenberg, S O, Leung
Publikováno v:
Cancer. 80
LL2 is a murine immunoglobulin (Ig)G2a-kappa anti-B-cell monoclonal antibody with proven targeting and therapeutic efficacy in the management of non-Hodgkin's lymphoma (NHL). The authors had previously generated a humanized LL2 (hLL2) that demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5edc4c556bf98efa2f55b0a5b1102a27
https://pubmed.ncbi.nlm.nih.gov/9406722
https://pubmed.ncbi.nlm.nih.gov/9406722
Publikováno v:
International journal of cancer. 71(3)
CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f970d3c5f67b82d2f419b94f9e36d6a9
https://pubmed.ncbi.nlm.nih.gov/9139880
https://pubmed.ncbi.nlm.nih.gov/9139880
Publikováno v:
Cancer research. 55
RS7, a murine IgG1 antibody raised against human lung carcinoma, possesses pancarcinoma reactivity. The antigen defined by this antibody is present in tumors of the lung, stomach, bladder, breast, ovary, uterus, and prostate. Efficient targeting and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a49734f4296013e1664327aa55b977d8
https://pubmed.ncbi.nlm.nih.gov/7493360
https://pubmed.ncbi.nlm.nih.gov/7493360
Autor:
M J, Losman, S O, Leung, L B, Shih, J, Shevitz, R, Shukla, L, Haraga, D M, Goldenberg, H J, Hansen
Publikováno v:
Cancer research. 55
Anti-idiotype monoclonal antibodies (Mabs) to mLL2, an anti-B-cell lymphoma and CD22-specific murine IgG2a-kappa Mab, were generated by hybridoma technology from splenocytes of Copenhagen rats immunized with mLL2 F(ab')2. Mab WN, an IgG2a-kappa, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75e0ee3ad892483ca77abca4199d583f
https://pubmed.ncbi.nlm.nih.gov/7493380
https://pubmed.ncbi.nlm.nih.gov/7493380
Autor:
L B, Shih, S R, Thorpe, G L, Griffiths, H, Diril, G L, Ong, H J, Hansen, D M, Goldenberg, M J, Mattes
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 35(5)
Processing radiolabeled degradation products is the key factor affecting retention of antibodies within the cell. In this study, we have analyzed the processing of antibodies labeled in nine different ways.Antibodies were labeled with three different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9874043b71ece3a26b44cc9b94036fda
https://pubmed.ncbi.nlm.nih.gov/8176479
https://pubmed.ncbi.nlm.nih.gov/8176479
Publikováno v:
Cancer. 73
Previous experiments indicated that most antibodies binding to cell surface antigens are internalized gradually and degraded within lysosomes, with a half-life of degradation of approximately 1 day, for most antibodies. The research discussed in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60b4afe6ac7ae73b6bc4eb0669bbd326
https://pubmed.ncbi.nlm.nih.gov/8306261
https://pubmed.ncbi.nlm.nih.gov/8306261
Publikováno v:
Cancer research. 52(4)
The fate of monoclonal antibodies binding to the surface of human tumor cells in vitro was investigated. Seven antibodies, labeled with 125I, were tested on four cell lines, which included a melanoma and carcinomas of the ovary, kidney, and lung. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48e4baba559a14a243225bb537096fea
https://pubmed.ncbi.nlm.nih.gov/1737345
https://pubmed.ncbi.nlm.nih.gov/1737345
Publikováno v:
Cancer research. 51(16)
Anthracycline, either daunomycin or doxorubicin, was site specifically attached to the carbohydrate moiety of a monoclonal anticarcinoembryonic antigen antibody by using amino-dextran as the intermediate carrier. The reaction resulted in an immunocon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3869eeaa513b0904bea62e9d2f448d6d
https://pubmed.ncbi.nlm.nih.gov/1868440
https://pubmed.ncbi.nlm.nih.gov/1868440