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Akademický článek

Platelet-neutrophil interactions. 12S,20- and 5S,12S-dihydroxyeicosapentaenoic acids: two novel neutrophil metabolites from platelet-derived 12S-hydroxyeicosapentaenoic acid.

Autor: C von Schacky, A J Marcus, L B Safier, H L Ullman, N Islam, M J Broekman, S Fischer

Publikováno v: Journal of Lipid Research, Vol 31, Iss 5, Pp 801-810 (1990)

Dietary marine n-3 polyunsaturated fatty acids have demonstrated an antiinflammatory potential in epidemiologic and intervention studies in humans. Proposed mechanisms, involving only leukocytes, fall short of explaining this potential completely. En

Externí odkaz: https://doaj.org/article/d3145e738c6146a9b589ac2e89f0bb25

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The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39

Autor: Richard B. Gayle, T. N. Alyonycheva, Aaron J. Marcus, M. A. Schoenborn, Charles R. Maliszewski, Joan H.F. Drosopoulos, M J Broekman, K. A. Schooley, L. B. Safier, Katherine A. Hajjar, David N. Posnett, Naziba Islam

Publikováno v: Journal of Clinical Investigation. 99:1351-1360

We previously demonstrated that when platelets are in motion and in proximity to endothelial cells, they become unresponsive to agonists (Marcus, A.J., L.B. Safier, K.A. Hajjar, H.L. Ullman, N. Islam, M.J. Broekman, and A.M. Eiroa. 1991. J. Clin. Inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d2bc4023013fb0fcf02faac654470d
https://doi.org/10.1172/jci119294

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Prothrombotic Effects of Erythrocytes on Platelet Reactivity

Autor: Aaron J. Marcus, M. Teresa Santos, L B Safier, Juana Vallés, Justo Aznar, M. Johan Broekman

Publikováno v: Circulation. 95:63-68

Background Aspirin effectively reduces the incidence of secondary vascular occlusive events in only 25% of patients. Low-dose aspirin as currently used blocks platelet production of prothrombotic thromboxane A 2 and allows endothelial synthesis of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa7953ddb805fdb1874b1d6c525f1ed5
https://doi.org/10.1161/01.cir.95.1.63

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Thrombosis and Inflammation as Multicellular Processes: Significance of Cell-Cell Interactions

Autor: L. B. Safier, C von Schacky, W. E. Kaminski, Aaron J. Marcus, E. Jendraschak, M. J. Broekman, N Islam, J. H. Fliessbach, Katherine A. Hajjar, Roy L. Silverstein

Publikováno v: Thrombosis and Haemostasis. 74:213-217

Platelet activation as a result of vascular injury provokes endothelial cells to respond in a manner which limits or reverses the occlusive consequences of platelet accumulation. If the agonistic forces are strong, platelet accumulation is irreversib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edd9496a527704ccba8df5c34bc0b39e
https://doi.org/10.1055/s-0038-1642679

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Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins

Autor: L B Safier, Justo Aznar, Aaron J. Marcus, N Islam, J. Valles, M T Santos, M J Broekman, H L Ullman

Publikováno v: Journal of Clinical Investigation. 92:1357-1365

Unstimulated neutrophils inhibited activation and recruitment of thrombin- or collagen-stimulated platelets in an agonist-specific manner. This occurred under conditions of close physical cell-cell contact, although biochemical adhesion between the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440a74b946aaf52790f3c8ca2a6ad198
https://doi.org/10.1172/jci116709

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Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells

Autor: N Islam, L B Safier, M J Broekman, Aaron J. Marcus, A M Eiroa, H L Ullman, Katherine A. Hajjar

Publikováno v: Journal of Clinical Investigation. 88:1690-1696

We previously reported that platelets become unresponsive to agonists when stimulated in combined suspension with aspirin-treated human umbilical vein endothelial cells. Inhibition occurred concomitant with metabolism of platelet-derived endoperoxide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f4f0d2d12647f1f28d702161a25097
https://doi.org/10.1172/jci115485

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Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment

Autor: L B Safier, Justo Aznar, V Martinez-Sales, Maria-Teresa Santos, Juana Vallés, M J Broekman, Aaron J. Marcus, Manuel Portolés

Publikováno v: Blood. 78:154-162

Erythrocytes promoted platelet reactivity in a plasma medium, as demonstrated in an in vitro system that independently evaluated the biochemistry of platelet activation and recruitment. The prothrombotic erythrocyte effects were metabolically regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ff24b8c51d6a6205091c5488d4016b5
https://doi.org/10.1182/blood.v78.1.154.154

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Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes. A new approach to platelet activation and recruitment

Autor: J. Valles, Aaron J. Marcus, A M Eiroa, M J Broekman, N Islam, L B Safier, M T Santos, H L Ullman, Justo Aznar

Publikováno v: Journal of Clinical Investigation. 87:571-580

Erythrocytes are known to influence hemostasis. Bleeding times are prolonged in anemia and corrected by normalizing the hematocrit. We now demonstrate that intact erythrocytes modulate biochemical and functional responsiveness of activated platelets.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ee40929cd9509ba103279cf78018a
https://doi.org/10.1172/jci115032

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