Collateral Damage Occurs When Using Photosensitizer Probes to Detect or Modulate Nucleic Acid Modifications

Autor: Aaron M. Fleming, Michael B. Chabot, Ngoc L. B. Nguyen, Cynthia J. Burrows

Publikováno v: Angew Chem Int Ed Engl

Nucleic acids are chemically modified to fine-tune their properties for biological function. Chemical tools for selective tagging of base modifications enables new approaches; the photosensitizers riboflavin and anthraquinone were previously proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ed6b7a6db616bf56cea2207993fab2
https://doi.org/10.1002/anie.202110649

Differing effects of cholesterol and taurocholate on steady state hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase activities and mRNA levels in the rat.

Autor: S Shefer, L B Nguyen, G Salen, G C Ness, I R Chowdhary, S Lerner, A K Batta, G S Tint

Publikováno v: Journal of Lipid Research, Vol 33, Iss 8, Pp 1193-1200 (1992)

We investigated the effects of cholesterol, cholestyramine, and taurocholate feeding on steady state specific activities and mRNA levels of hepatic 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and cholesterol 7 alpha-hydroxylase in the rat. Interru

Externí odkaz: https://doaj.org/article/b52a0cc42441478eaa33b876b7381605

Glycine-induced neurotoxicity in organotypic hippocampal slice cultures

Autor: A. Barth, L. Barth, L. B. Nguyen, David W. Newell

Publikováno v: Barth, A.; Nguyen, L. B.; Barth, L.; Newell, D. W. (2005). Glycine-induced neurotoxicity in organotypic hippocampal slice cultures. Experimental brain research, 161(3), pp. 351-357. Springer 10.1007/s00221-004-2079-7

The role of the neutral amino acid glycine in excitotoxic neuronal injury is unclear. Glycine coactivates glutamate N-methyl-D-aspartate (NMDA) receptors by binding to a distinct recognition site on the NR1 subunit. Purely excitatory glycine receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83f36ef0debc5087c030e1df1f786da
http://doc.rero.ch/record/321837/files/221_2004_Article_2079.pdf

Regulation of rat hepatic 3β-hydroxysterol Δ7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation

Autor: Robert J. Desnick, Ashok K. Batta, S Shefer, Gerald Salen, G.S. Tint, Yiannis A. Ioannou, Akira Honda, L B Nguyen

Publikováno v: Journal of Lipid Research, Vol 39, Iss 12, Pp 2471-2476 (1998)

The mechanism for the catalytic reduction of the double bond at C-7,8 in 7-dehydrocholesterol by 3β-hydroxysterol Δ7-reductase was investigated by testing structurally related sterols as substrates and potential inhibitors. The hepatic smooth endop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9165f5c46080efa52b4b87b974d311b7
https://doi.org/10.1016/s0022-2275(20)33327-7

Blocking late cholesterol biosynthesis inhibits the growth of transplanted Morris hepatomas (7288CTC) in rats

Autor: Thomas S. Chen, G.S. Tint, Gerald Salen, Sarah Shefer, Guorong Xu, Michael A. Lea, L B Nguyen, Ashok K. Batta

Publikováno v: Hepatology. 24:440-445

The conversion of 7-dehydrocholesterol to cholesterol is the last reaction in the cholesterol biosynthesis pathway catalyzed by the microsomal enzyme, 7-dehydrocholesterol-delta 7-reductase. We studied whether malignant tumor growth that depends on c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143538a9c2597137486617aadf4b3147
https://doi.org/10.1002/hep.510240224