Zobrazeno 1 - 10
of 46
pro vyhledávání: '"L B, Mellett"'
Publikováno v:
Current Medical Research and Opinion. 5:9-12
SummaryA fluorescence assay for indapamide which is both sensitive and capable of handling large numbers of samples has been developed. Reaction of indapamide with NaOH at 100°C has been shown to yield a fluorescent product, which has excitation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d51aa3b40ca208bdde884d24db095f44
https://doi.org/10.1185/03007997709110218
https://doi.org/10.1185/03007997709110218
Autor:
L. B. Mellett, L. A. Woods
Publikováno v:
Experimental Biology and Medicine. 106:221-223
The results of urinary excretion and C/sup 14/O/sub 2/ elimination experiments in dogs and monkeys receiving 2.0 mg/kg of N-C/sup 14/-methyl morphine, subcutaneously, were as follows: dogs excreted 13 to 15% of the total dose as free morphine and 48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee7876cb4d1037164afe934a3a829ed
https://doi.org/10.3181/00379727-106-26293
https://doi.org/10.3181/00379727-106-26293
Publikováno v:
Cancer treatment reports. 60(3)
A new bioassay method utilizing laser light scattering from suspensions of drug-sensitive bacteria has been developed for the estimation of antitumor drugs in biologic samples. Changes in the light-scattering patterns of antibiotic-treated bacteria h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fca1f11bc49d7d7b519b9eb2188fa5a7
https://pubmed.ncbi.nlm.nih.gov/816466
https://pubmed.ncbi.nlm.nih.gov/816466
Publikováno v:
Research communications in chemical pathology and pharmacology. 20(2)
A bioassay method for the estimation of ara-C in biological samples which utilizes laser light scattering from suspensions of drug-sensitive bacteria has been developed. The species employed in the assay was Streptococcus faecium var. durans resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::552e326f965b9afd628b84ffe582b20b
https://pubmed.ncbi.nlm.nih.gov/674821
https://pubmed.ncbi.nlm.nih.gov/674821
Autor:
R L, Furner, L B, Mellett
Publikováno v:
Cancer research. 35(7)
Extracts of solid mouse tumors were examined for deoxycytidine kinase and deaminase activities. 1beta-D-Arabinofuranosylcytosine nucleotide was formed at a rate of 45 nmoles/hr by Glioma 26/57 and only 14 nmoles/hr by Ridgway osteogenic sarcoma. Deam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee59427f4dfe7f8aff37e71c0e63b5e6
https://pubmed.ncbi.nlm.nih.gov/165884
https://pubmed.ncbi.nlm.nih.gov/165884
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 194(1)
The phosphorylation of 1-beta-D-arabinofuranosylcytosine (ara-C) was studied in cell-free extracts from a variety of solid mouse tumors, L1210 ascites and in normal liver and spleen. Two apparent Michaelis constants were observed for kinase activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56f699c6918f6ed79886916a4c1efcaa
https://pubmed.ncbi.nlm.nih.gov/1057009
https://pubmed.ncbi.nlm.nih.gov/1057009
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 200(3)
A pharmacokinetic model is presented for the distribution of actinomycin-D in the beagle dog. A simple, flow-limited model provides good simulations of the data at doses of 0.6 mg/m2 (0.03 mg/kg) and 2.7 mg/m2 (0.135 mg/kg) for most normal tissues. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::132d88ca07b9812910444ffcc23f66a9
https://pubmed.ncbi.nlm.nih.gov/557542
https://pubmed.ncbi.nlm.nih.gov/557542
Autor:
R L, Furner, L B, Mellett
Publikováno v:
Cancer chemotherapy reports. 59(4)
Inhibition of the deamination of 14C-cytosine arabinoside by two lots of tetrahydrouridine was studied in monkey serum. The average inhibition of deaminase activity was 78% for tetrahydrouridine lot AJ39 (1.0 muM) when the concentration of cytosine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5d2636a3ce5c3237a2d9fe6e64ff686
https://pubmed.ncbi.nlm.nih.gov/809135
https://pubmed.ncbi.nlm.nih.gov/809135
Publikováno v:
Research communications in chemical pathology and pharmacology. 21(3)
Bioassay methods for actinomycin D, 6-thioguanine, and adriamycin which utilize laser light scattering from suspensions of drug-sensitive bacteria have been developed. In 3 hours, serum and urine levels of the 3 drugs can be reproducibily measured. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4208ce2d55a66510796839ccbcfa6ab2
https://pubmed.ncbi.nlm.nih.gov/100836
https://pubmed.ncbi.nlm.nih.gov/100836
Autor:
W M, Galbraith, L B, Mellett
Publikováno v:
Cancer chemotherapy reports. 59(6)
Tissue concentration of 3H-actinomycin D have been determined in the rat, monkey, and dog after an iv dose of 0.6 mg/m2 body surface area. The drug-tissue half-life was determined for various tissues of the rat, monkey, and dog. A mean drug-tissue ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0a707c4eb8e71bd2a3ddf321a446c6c
https://pubmed.ncbi.nlm.nih.gov/816458
https://pubmed.ncbi.nlm.nih.gov/816458