Zobrazeno 1 - 10
of 74
pro vyhledávání: '"L B, Gorbacheva"'
Autor:
L. B. Gorbacheva, Anna Grekhova
Publikováno v:
Bulletin of Experimental Biology and Medicine. 160:709-711
The study revealed a two-fold elevation of ROS production in peripheral blood lymphocytes of the patients with prostate cancer (from 0.48±0.04 to 0.93±0.12 rel. units) together with significant variability of individual values. Hormone therapy had
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 7:226-230
Comparative studies on the genotoxic activity of cisplatin and morfozol, the first representative of a new class of cation-anion complexes of palladium [AH]2[PdCl4] (where A—methylmorpholine), have been performed using human lymphocytes in vitro. T
Publikováno v:
Cell and Tissue Biology. 5:29-36
Melanoma is a highly aggressive tumor of melanocytes. The efficacy of different cytotoxic chemotherapy regimens does not exceed 20%. The search for markers for patient sensitivity to chemotherapy provides a rational basis for the development of cytot
Publikováno v:
Russian Journal of Genetics. 46:146-156
Melanoma is among the most aggressive malignancies. Tumors with a thickness of 4 mm can produce metastases, and the mean survival of the patients is 9 months. The review presents modern classification of the melanoma types based on cytological and mo
Autor:
L. Yu. Dederer, L. B. Gorbacheva
Publikováno v:
Pharmaceutical Chemistry Journal. 43:73-76
The review considers modern data on the pre- and post-replicative repair of DNA damage induced by methylating agents such as N-methyl-N-nitrosourea, temozolomide, procarbazine, dacarbazine, and aranoza. These drugs are used in the treatment of variou
Publikováno v:
Russian Journal of Coordination Chemistry. 29:489-493
Interaction of K2[PdCl4] (I) and (C5H12NO)2[PdCl4] (II) with DNA in vitro is studied. No fragmentation of DNA occurs under the action of II. The interstrand cross-links are formed due to the formation of complexes with purine and pyrimidine bases; no
Autor:
S. A. Goncharova, A. G. Tikhomirov, Vasily D. Sen, A. V. Pis'menskii, T. A. Raevskaya, Ludmila Mihailovna Volkova, Nina P. Konovalova, L. B. Gorbacheva, N. A. Rukina, Valery V. Tkachev
Publikováno v:
Russian Chemical Bulletin. 49:1613-1619
Mixed-ligand platinum complexescis-PtII(R6NH2)(NH3)X2 andcis-PtII(R5NH2)(NH3)X2 (R6 is 2,2,6,6-tetramethyl-4-piperidyl-1-oxyl and R5 is 2,2,5,5-tetramethyl-3-pyrrolidinyl-1-oxyl) were synthesized by either the reaction of aminonitroxides RNH2 with Na
Autor:
I. Y. Dydykina, N. A. Semenova, K. P. Laktionova, V. A. Gorbunova, L. B. Gorbacheva, L. Y. Dederer, A. G. Tikhomirov
Publikováno v:
Bulletin of Experimental Biology and Medicine. 130:701-704
The pool of low-molecular-weight metabolites was studied in patients with breast cancer by high-resolution 1H-NMR spectroscopy. In order to predict the efficiency of treatment, mathematical regression analysis was carried out with consideration for s
Autor:
L. B. Gorbacheva, A. S. Terekhov, S. M. Adekenov, L. Yu. Dederer, N. S. Zhangabylov, S. V. Vasil’eva
Publikováno v:
Pharmaceutical Chemistry Journal. 38:651-653
Publikováno v:
Voprosy onkologii. 57(2)
Patients with advanced malignant melanoma have poor prognosis as conventional chemotherapy induces complete response in a very small fraction (not more than 20%). One of research strategies aimed at raising its efficiency is the search for markers pr