Zobrazeno 1 - 10
of 19
pro vyhledávání: '"L Ashley Watson"'
Autor:
Nader Morshed, William T Ralvenius, Alexi Nott, L Ashley Watson, Felicia H Rodriguez, Leyla A Akay, Brian A Joughin, Ping‐Chieh Pao, Jay Penney, Lauren LaRocque, Diego Mastroeni, Li‐Huei Tsai, Forest M White
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp 1-27 (2020)
Abstract Alzheimer’s disease (AD) is characterized by the appearance of amyloid‐β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK
Externí odkaz:
https://doaj.org/article/7b9677d83e734c9bb4414abb7d975e62
Autor:
L. Ashley Watson, Hiruy S. Meharena
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent aneuploidy observed in the human population and represents the most common genetic form of intellectual disability and early-onset Alzheimer’s disease (AD). Individua
Externí odkaz:
https://doaj.org/article/9d16e109b8cf4c039dc006dec7dbb3ce
Autor:
Hiruy S. Meharena, Asaf Marco, Vishnu Dileep, Elana R. Lockshin, Grace Y. Akatsu, James Mullahoo, L. Ashley Watson, Tak Ko, Lindsey N. Guerin, Fatema Abdurrob, Shruthi Rengarajan, Malvina Papanastasiou, Jacob D. Jaffe, Li-Huei Tsai
Publikováno v:
Cell Stem Cell
Down syndrome (DS) is a genetic disorder driven by the triplication of chromosome 21 (T21) that is characterized by a wide-range of neurodevelopmental and physical disabilities. Transcriptomic analysis of tissue samples from individuals with DS has r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3119ac0c9f90e9f1bf1a47524a9b8a
https://europepmc.org/articles/PMC8805993/
https://europepmc.org/articles/PMC8805993/
Autor:
Ping-Chieh Pao, Hugh P. Cam, Alexi Nott, Elizabeta Gjoneska, Sara Elmsaouri, Wen-Chin Huang, Trongha X. Phan, Debasis Patnaik, Jay Penney, Lorena Pantano, Li-Huei Tsai, Fan Gao, L. Ashley Watson, Jun Wang, Chinnakkaruppan Adaikkan, Audrey Lee, Stephen J. Haggarty, Ling Pan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
DNA damage contributes to brain aging and neurodegenerative diseases. However, the factors stimulating DNA repair to stave off functional decline remain obscure. We show that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) repair in the brain. HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffdb9ace79334086c2267aa5f7389de
https://doi.org/10.1038/s41467-020-16361-y
https://doi.org/10.1038/s41467-020-16361-y
Autor:
William T. Ralvenius, L. Ashley Watson, Jay Penney, Ping-Chieh Pao, Diego Mastroeni, Lauren LaRocque, Leyla Anne Akay, Brian A. Joughin, Forest M. White, Alexi Nott, Felicia H. Rodriguez, Li-Huei Tsai, Nader Morshed
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 12, Pp n/a-n/a (2020)
Molecular Systems Biology
Molecular Systems Biology
SummaryAlzheimer’s disease (AD) is characterized by the appearance of amyloid-β plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Using mass spectrometry, we have quantified the phosphoproteome of the CK-p25,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6232f4e01e872bbf96b9aff45f0defdd
https://doi.org/10.1101/2020.05.12.090688
https://doi.org/10.1101/2020.05.12.090688
Autor:
Jay Penney, Debasis Patnaik, Oleg Kritskiy, Stephen J. Haggarty, Ping-Chieh Pao, Jinsoo Seo, M. Catarina Silva, Li-Huei Tsai, Scarlett J. Barker, Michael Bula, Audrey Lee, L Ashley Watson
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This effect is mediated by pathological cleavage of the Cdk5 activator p35 to produce the truncated product p25, exhibiting increased stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311ac322b1ca13829e37f591ab8a043e
https://doi.org/10.1101/2020.05.12.090472
https://doi.org/10.1101/2020.05.12.090472
Autor:
Diane Lucente, M. Catarina Silva, Jay Penney, Stephen J. Haggarty, Oleg Kritskiy, Waseem K. Raja, Yuan-Ta Lin, Dilip Dey, Bradford C. Dickerson, L. Ashley Watson, Jinsoo Seo, Steven D. Sheridan, James F. Gusella, Tak Ko, Scarlett J. Barker, Li-Huei Tsai, Sukhee Cho
Publikováno v:
The Journal of Neuroscience. 37:9917-9924
Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated with neurodegenerative disorders, including Alzheimer's disease. Previously, we showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef6d51bca83251de08e79b9b3137c15
https://doi.org/10.1523/jneurosci.0621-17.2017
https://doi.org/10.1523/jneurosci.0621-17.2017
Autor:
L Ashley Watson, Li-Huei Tsai
Publikováno v:
PMC
Different aspects of learning, memory, and cognition are regulated by epigenetic mechanisms such as covalent DNA modifications and histone post-translational modifications. More recently, the modulation of chromatin architecture and nuclear organizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321b7f60da16335000cccb419cd17ff8
https://doi.org/10.1016/j.conb.2016.12.002
https://doi.org/10.1016/j.conb.2016.12.002
Autor:
Anthony J Martorell, Carol Y. Liu, L Ashley Watson, Fan Gao, Richard Rueda, Alexi Nott, Omer Durak, Yea Jin Kaeser-Woo, Li-Huei Tsai
Publikováno v:
Nature neuroscience
De novo mutations in CHD8 are strongly associated with autism spectrum disorder (ASD), however the basic biology of CHD8 remains poor understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457aff7f52680533533472213bd22870
https://doi.org/10.1038/nn.4400
https://doi.org/10.1038/nn.4400
Publikováno v:
Epigenomics. 7:1365-1378
ATRX was identified over 20 years ago as the gene responsible for a rare developmental disorder characterized by α-thalassemia and intellectual disability. Similarities to the sucrose nonfermentable SNF2 type chromatin remodelers initially suggested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fe08b72a8e809e3ce10637217cfb2e
https://doi.org/10.2217/epi.15.82
https://doi.org/10.2217/epi.15.82