Zobrazeno 1 - 10
of 480
pro vyhledávání: '"L Alhonen"'
Publikováno v:
Molecular Endocrinology. 7:1430-1436
Polyamines are believed to participate in the induction of cell growth, differentiation, and proliferation, but their role in spermatogenesis has remained obscure. Two transgenic mouse lines (K2 and K15) that overexpress the human ornithine decarboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d087209eb7e1d3502ba03b016c768d
https://doi.org/10.1210/mend.7.11.8114757
https://doi.org/10.1210/mend.7.11.8114757
Autor:
Sándor Berczi, A Siska, R Sinervirta, Béla Iványi, Péter Hegyi, L Alhonen, Tibor Wittmann, Tamás Takács, V Venglovecz, Sándor Dósa, Zoltán Rakonczay, György Biczó
Publikováno v:
Zeitschrift für Gastroenterologie. 48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35451f2bb9ed08427e4291afb887c098
https://doi.org/10.1055/s-0030-1254744
https://doi.org/10.1055/s-0030-1254744
Akademický článek
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Autor:
A R, Khomutov, T A, Keinanen, N A, Grigorenko, M T, Hyvonen, A, Uimari, M, Pietila, M, Cerrada-Gimenez, A R, Simonian, M A, Khomutov, J, Verspalainen, L, Alhonen, J, Janne
Publikováno v:
Molekuliarnaia biologiia. 43(2)
Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the enzymes of polyamine metabolism and functions of spermine and spermidine in vitro and in vivo. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a73a5ce8b95edc593d3d663a495d251
https://pubmed.ncbi.nlm.nih.gov/19425496
https://pubmed.ncbi.nlm.nih.gov/19425496
Autor:
N A, Grigorenko, J, Vepsalainen, A, Jarvinen, T A, Keinanen, L, Alhonen, J, Janne, A R, Khomutov
Publikováno v:
Bioorganicheskaia khimiia. 31(2)
alpha-Methylspermine and alpha,alpha'-dimethylspermine were synthesized in high overall yields starting from N-(benzyloxycarbonyl)-3-aminobutanol in order to study polyamine biochemistry in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69d0641a3c17608b98bc36c79b0cdfd2
https://pubmed.ncbi.nlm.nih.gov/15889795
https://pubmed.ncbi.nlm.nih.gov/15889795
Autor:
N A, Grigorenko, J, Vepsalainen, A, Jarvinen, T A, Keinanen, L, Alhonen, J, Janne, A M, Kritsyn, A R, Khomutov
Publikováno v:
Bioorganicheskaia khimiia. 30(4)
A five-step synthesis of alpha-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermidine N'-acetyltransferase, from ethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::426482845747d3253a244c99c1c7e016
https://pubmed.ncbi.nlm.nih.gov/15469020
https://pubmed.ncbi.nlm.nih.gov/15469020
Publikováno v:
The Journal of investigative dermatology. 116(5)
We recently generated a transgenic mouse line with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase. Phenotypic changes in these animals included permanent loss of hair at the age of 3 wk. We have now f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fac1318d54a5613e2e1006f18c5bc9fd
https://pubmed.ncbi.nlm.nih.gov/11348473
https://pubmed.ncbi.nlm.nih.gov/11348473
Publikováno v:
The European journal of neuroscience. 12(2)
We recently generated a transgenic mouse line with activated polyamine catabolism through overexpression of spermidine/spermine N1-acetyltransferase (SSAT). A detailed analysis of brain polyamine concentrations indicated that all brain regions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f5c99925bdf3dd1bb62328356ff4a48
https://pubmed.ncbi.nlm.nih.gov/10712633
https://pubmed.ncbi.nlm.nih.gov/10712633
Publikováno v:
Molecular pharmacology. 55(4)
We have recently generated transgenic mice in which polyamine catabolism has been activated by overexpressing the rate-limiting enzyme of polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT). These animals have now been tested for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c4f48de3af4c9a340f2a301b9d81fac
https://pubmed.ncbi.nlm.nih.gov/10101027
https://pubmed.ncbi.nlm.nih.gov/10101027
Publikováno v:
Biotechnology annual review. 4
Since the generation of the first transgenic mice in 1980, transgene technology has also been successfully applied to large farm animals. Although this technology can be employed to improve certain production traits of livestock, this approach has no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ceb638cebb4263669a869fc03b299920
https://pubmed.ncbi.nlm.nih.gov/9890138
https://pubmed.ncbi.nlm.nih.gov/9890138