Zobrazeno 1 - 10
of 52
pro vyhledávání: '"L A Turka"'
Autor:
X X Zheng, M H Sayegh, X G Zheng, Y Li, P S Linsley, R Peach, F Borriello, T B Strom, A H Sharpe, L A Turka
Publikováno v:
The Journal of Immunology. 159:1169-1173
Blockade of CD28-mediated T cell costimulatory signals produces effective immunosuppression of a variety of T cell-dependent in vivo immune responses, including autoimmune disorders and transplant rejection. The soluble fusion protein CTLA4Ig, which
Autor:
B. J. Nickoloff, L. A. Turka
Publikováno v:
Science. 273:1477d-1480
Publikováno v:
The Journal of Immunology. 157:117-125
Blockade of costimulation through the B7-CD28 pathway by CTLA4Ig can lead to Ag-specific T cell tolerance. Most models studied to date involve a Th1-dependent response. To investigate whether the tolerizing effects of CTLA4Ig might vary depending upo
Publikováno v:
The Journal of Immunology. 156:2294-2299
A single dose of CTLA4Ig, an inhibitor of CD28-mediated T cell costimulation, given 2 days after transplantation induces specific unresponsiveness to alloantigens in vivo. However, the mechanisms responsible are unknown. Using pigeon cytochrome c as
Publikováno v:
The Journal of Immunology. 154:2668-2677
Regulation of immune responses depends on interactions between APCs and T cells. Such cellular interactions are mediated by surface molecules including MHC class II Ags (DR) and CD28 ligands B7-1 (CD80) and B7-2 (CD86). Recent evidence indicates that
Publikováno v:
The Journal of Immunology. 154:1699-1706
A20 is a cytokine-inducible primary response gene that encodes a protein that inhibits apoptosis. We cloned and characterized a murine A20 cDNA and mapped the gene to mouse chromosome 10, 3.5 centimorgans proximal to the c-myb locus. Using the murine
Publikováno v:
The Journal of Immunology. 152:5189-5198
By using superantigens, we have found previously that keratinocytes activated by IFN-gamma could serve as accessory cells, providing costimulatory signals needed to induce T cell proliferation. Here, we compared the profile of cytokines produced by T
Publikováno v:
The Journal of Immunology. 151:6535-6545
The relative contribution of dermal-derived immunocompetent cells to the overall immunologic response in skin has been hampered by the lack of appropriate isolation techniques. In this report, we provide a purification schema that reliably yields hig
Publikováno v:
The Journal of Immunology. 151:83-91
To ensure that the mature T cell repertoire is MHC-restricted yet not autoreactive, cortical thymocytes that express low levels of the TCR/CD3 complex along with CD4 and CD8 (double positive cells) are subjected to positive and negative selection. Su
Publikováno v:
Blood. 80:2571-2576
A cDNA clone encoding a novel zinc finger protein expressed in lymphoid cells has been isolated. This protein contains 5 repeats of the C2H2 motif previously described in the Drosophila gap gene, Kruppel, which is involved in embryo segmentation. Nor