Zobrazeno 1 - 10
of 228
pro vyhledávání: '"L A Maher"'
Autor:
Elizabeth P. Lewis, Fatimah Al Khazal, Brandon Wilbanks, Naomi M. Gades, Patricia Ortega‐Sáenz, José López‐Barneo, Igor Adameyko, L. James Maher III
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 9, Pp 327-336 (2024)
Abstract In humans, loss of heterozygosity for defective alleles of any of the four subunits of mitochondrial tricarboxylic acid cycle enzyme succinate dehydrogenase (SDH, also Complex II of the electron transport chain) can lead to paraganglioma tum
Externí odkaz:
https://doaj.org/article/29cd999d7e6e4937bf53906a8080350f
Autor:
Donglin Ding, Alexandra M. Blee, Jianong Zhang, Yunqian Pan, Nicole A. Becker, L. James Maher, Rafael Jimenez, Liguo Wang, Haojie Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG fusion and TP53 mutation / deletion co-occur in PCa patient specimens and this co-occurrence
Externí odkaz:
https://doaj.org/article/397f26f685f14e35b502865eb0a5564e
Autor:
Rania S. M. Ibrahim, Manar A. E. L. O. Maher, Solava Abdalaziz, Samar Amer, Doaa Shafie, Soha T. Hamed
Publikováno v:
The Egyptian Journal of Radiology and Nuclear Medicine, Vol 50, Iss 1, Pp 1-14 (2019)
Abstract Background Characterization of an ovarian lesion is a diagnostic challenge. A correct preoperative assessment is of great importance so as to arrange adequate therapeutic procedures. The aim of the current study is to evaluate the diagnostic
Externí odkaz:
https://doaj.org/article/951c565bbcb54ea79ab63060d7384477
Autor:
John A. Smestad, L. James Maher
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-19 (2019)
Abstract Background Succinate dehydrogenase (SDH) loss and mastermind-like 3 (MAML3) translocation are two clinically important genetic alterations that correlate with increased rates of metastasis in subtypes of human paraganglioma and pheochromocyt
Externí odkaz:
https://doaj.org/article/582280d42a194f5bad97b53b0f35b1a3
Autor:
Robin M. Heider, John A. Smestad, Hernan Nicolas Lemus, Brandon Wilbanks, Arthur E. Warrington, Justin P. Peters, Moses Rodriguez, L. James Maher, III
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 270-277 (2018)
Multiple sclerosis (MS) is a debilitating disease for which regenerative therapies are sought. We have previously described human antibodies and DNA aptamer-streptavidin conjugates that promote remyelination after systemic injection into mice infecte
Externí odkaz:
https://doaj.org/article/af9769126cd84bf4b41483b4800c8495
Publikováno v:
iScience, Vol 2, Iss , Pp 63-75 (2018)
Summary: Succinylation is a post-translational protein acylation modification that converts the cationic lysine side chain to an anion with large potential impacts on protein structure and function. Here we characterize the epigenome-wide distributio
Externí odkaz:
https://doaj.org/article/fc66aeb94f1740bead8cbe0a9f9ea618
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227033 (2019)
Mitochondrial disorders arise from defects in nuclear genes encoding enzymes of oxidative metabolism. Mutations of metabolic enzymes in somatic tissues can cause cancers due to oncometabolite accumulation. Paraganglioma and pheochromocytoma are examp
Externí odkaz:
https://doaj.org/article/5bedcaf70472487381d946ce858f1afe
Publikováno v:
PNAS Nexus. 2
The efficient and specific delivery of functional cargos such as small-molecule drugs, proteins, or nucleic acids across lipid membranes and into subcellular compartments is a significant unmet need in nanomedicine and molecular biology. Systematic E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018c3f4cdb6eb99f7f395d1aa6d81ba8
https://doi.org/10.1093/pnasnexus/pgad151
https://doi.org/10.1093/pnasnexus/pgad151
Autor:
Brandon Wilbanks, Keenan Pearson, Shane R. Byrne, Laura B. Bickart, Peter C. Dedon, L. James Maher
Publikováno v:
Bioconjugate Chemistry.
Advances in peroxidase- and biotin ligase-mediated signal amplification have enabled high-resolution subcellular mapping of endogenous RNA localization and protein-protein interactions. Application of these technologies has been limited to RNA and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824fcd61a45977650065652582889fc4
https://doi.org/10.1021/acs.bioconjchem.2c00475
https://doi.org/10.1021/acs.bioconjchem.2c00475
Publikováno v:
Biology Open, Vol 4, Iss 10, Pp 1281-1289 (2015)
Hypoxia inducible factors (HIFs) play vital roles in cellular maintenance of oxygen homeostasis. These transcription factors are responsible for the expression of genes involved in angiogenesis, metabolism, and cell proliferation. Here, we generate a
Externí odkaz:
https://doaj.org/article/686e40504c884bacba8638b21a0a37a8