Zobrazeno 1 - 10
of 67
pro vyhledávání: '"L A, Zhmurenko"'
Autor:
I. O. Gaydukov, S. A. Litvinova, T. A. Voronina, L. N. Nerobkova, L. A. Zhmurenko, G. V. Mokrov, G. G. Avakyan, I. S. Kutepova
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 9, Iss 2, Pp 57-66 (2017)
Objective of the research is to evaluate the anticonvulsant effect of the new original compound GIZH-298 (4-benzoylpyridine oxime derivative) versus valproic acid (VPA) in a model of epilepsy in rats with cobalt-induced lesions.Materials and methods.
Externí odkaz:
https://doaj.org/article/4ba1dec32ac242fba342a3a42170f35b
Autor:
L. A. Zhmurenko, G. V. Mokrov, L. N. Nerobkova, S. A. Litvinova, I. O. Gaydukov, T. A. Voronina, T. A. Gudasheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 22-26 (2017)
Novel derivative of benzoylpyridine oximes - GIZH-298 (4-benzoylpyridine 0-(2-morpholinoethyl) oxime oxalate) was designed and synthesized in this work. This compound has a broad spectrum of anticonvulsant effects, eliminating primary generalized sei
Externí odkaz:
https://doaj.org/article/7e930911f8374b798f0796275a46c084
Autor:
S. A. Litvinova, T. A. Voronina, V. S. Kudrin, I. O. Gaydukov, L. N. Nerobkova, M. B. Pisclova, G. G. Avakyan, L. А. Zhmurenko
Publikováno v:
Эпилепсия и пароксизмальные состояния, Vol 8, Iss 3, Pp 19-26 (2016)
The aim of this study was to investigate the electrophysiological and neurochemical mechanisms of the anticonvulsant effect of a new original compound GIZH-298 and to define the leading structure as the target for influence compound. Materials and Me
Externí odkaz:
https://doaj.org/article/cce4cd80ba204b99a9e970af5d264c5c
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 31-33 (2016)
The study of the neuroprotective properties new original compound GIZH-276 and evaluate changes activities of prolyl endopeptidase (PEP) and lactate dehydrogenase (LDH) in blood plasma of rats with post-traumatic hematoma (model of hemorrhagic stroke
Externí odkaz:
https://doaj.org/article/ea705f00fe784804ae2335eba8373cd1
Autor:
D. M. Ivasheva, S. A. Litvinova, T. A. Voronina, T. A. Gudasheva, A. G. Rebeko, G. V. Mokrov, L. A. Zhmurenko
Publikováno v:
Pharmaceutical Chemistry Journal. 54:997-1002
A new group of aminoalkyl dibenzofuranone oxime derivatives was designed and synthesized. Several compounds were found to exhibit anticonvulsant activity in the maximum electroshock test. The most active compound was 3,4,6,7,8,9-hexahydrodibenzo[b, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c52dc357af1fa855b222dba4177fa65
https://doi.org/10.1007/s11094-021-02309-z
https://doi.org/10.1007/s11094-021-02309-z
Autor:
L. M. Zhmurenko, Gan'shina Ts, R. S. Mirzoyan, I. N. Kurdyumov, Kurza Ev, Maslennikov Dv, A. I. Turilova
Publikováno v:
Pharmaceutical Chemistry Journal. 54:564-567
The cerebrovascular properties of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1(2H)-one O-(4-cinnamoyl)oxime (C21H21NO3, GIZ-272) were studied. The ability of GIZ-272 to improve the brain blood supply in rats subjected to global transient ischemia and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::366aeaa5cd064088663667c574c52cf1
https://doi.org/10.1007/s11094-020-02240-9
https://doi.org/10.1007/s11094-020-02240-9
Autor:
T. A. Voronina, G. V. Mokrov, T. A. Gudasheva, I. S. Kutepova, L. A. Zhmurenko, L. N. Nerobkova, A. G. Rebeko, S. A. Litvinova
Publikováno v:
Pharmaceutical Chemistry Journal. 53:997-1004
New dibenzofuranone-oxime derivatives were designed based on active structures of oxime esters. Compounds of the proposed group were synthesized using 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1(2H)-one oxime and aromatic acid chlorides. The anticonvuls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5f7de5d4d5f0fedde889f4963422f4e
https://doi.org/10.1007/s11094-020-02112-2
https://doi.org/10.1007/s11094-020-02112-2
Autor:
T. A. Voronina, T. S. Kalinina, A V Volkova, A A Shimshirt, K A Kasabov, L A Zhmurenko, N V Kudryashov
Publikováno v:
Bulletin of Experimental Biology and Medicine. 168:449-452
We studied the influence of intraperitoneal injection of ATP-sensitive potassium channels inhibitor glibenclamide in doses of 0.01, 0.1, 1, and 10 mg/kg on the effects of a new pyrazolo[C]pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656d500f700b38a045dfefc16125c0f3
https://doi.org/10.1007/s10517-020-04729-5
https://doi.org/10.1007/s10517-020-04729-5
Autor:
T. S. Kalinina, A A Shimshirt, L A Zhmurenko, T. A. Voronina, N V Kudryashov, E A Ivanova, A A Kurshin
Publikováno v:
Bulletin of Experimental Biology and Medicine. 168:453-456
It was shown that finasteride, a 5α-reductase inhibitor (50 mg/kg, intraperitoneally) produced analgesic and antiexudative effects in experimental peritonitis induced by intraperitoneal injection of 1% acetic acid. These results agree with published
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff55abbc749847330d4d8ceb2fe71fb
https://doi.org/10.1007/s10517-020-04730-y
https://doi.org/10.1007/s10517-020-04730-y
Autor:
L. N. Nerobkova, T. A. Gudasheva, S. A. Litvinova, L. A. Zhmurenko, G. V. Mokrov, I. G. Kovalev, T. A. Voronina
Publikováno v:
Pharmaceutical Chemistry Journal. 53:429-435
New 4-phenylpyrrolidone derivatives were designed from racetam structures that combine nootropic and anticonvulsant activity. The proposed compounds were synthesized using 4-phenylpyrrolidone and aromatic amines. The anticonvulsant activity of the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83b81e9b2d36b504694bf1f2da200428
https://doi.org/10.1007/s11094-019-02015-x
https://doi.org/10.1007/s11094-019-02015-x