Zobrazeno 1 - 10
of 183
pro vyhledávání: '"L A, Svensson"'
Autor:
Emmelie Cansby, Mara Caputo, Emma Andersson, Rasool Saghaleyni, Marcus Henricsson, Ying Xia, Bernice Asiedu, Matthias Blüher, L. Thomas Svensson, Andrew J. Hoy, Margit Mahlapuu
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 11, Pp 100669- (2024)
Metabolic dysfunction–associated steatotic liver disease has emerged as a leading global cause of chronic liver disease. Our recent translational investigations have shown that the STE20-type kinases comprising the GCKIII subfamily—MST3, STK25, a
Externí odkaz:
https://doaj.org/article/c9be240609c84bf68c43bf2811bc5a17
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Silencing of STK25, an STE20-type kinase, in human aortic endothelial and smooth muscle cells reduces lipid accumulation and suppresses inflammation and fibrotic pathways, ultimately exerting atheroprotective effects.
Externí odkaz:
https://doaj.org/article/c671ada46a694cea94aa6e66b65dc4a6
Autor:
Emmelie Cansby, Esther Nuñez-Durán, Elin Magnusson, Manoj Amrutkar, Sheri L. Booten, Nagaraj M. Kulkarni, L. Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 597-618 (2019)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been re
Externí odkaz:
https://doaj.org/article/9be6ef8a91c74cad8b389b66aebc0dd6
Autor:
Josefin Ahlqvist, Javier A. Linares-Pastén, Andrius Jasilionis, Martin Welin, Maria Håkansson, L. Anders Svensson, Lei Wang, Hildegard Watzlawick, Arnþór Ævarsson, Ólafur H. Friðjónsson, Guðmundur Ó. Hreggviðsson, Bernd Ketelsen Striberny, Eirin Glomsaker, Olav Lanes, Salam Al-Karadaghi, Eva Nordberg Karlsson
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:1384-1398
This study describes the structure of DNA polymerase I from Thermus phage G20c, termed PolI_G20c. This is the first structure of a DNA polymerase originating from a group of related thermophilic bacteriophages infecting Thermus thermophilus, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4308321c851b7f8e3f8685d99359f60d
https://doi.org/10.1107/s2059798322009895
https://doi.org/10.1107/s2059798322009895
Autor:
Per Greisen, Li Yi, Rong Zhou, Jian Zhou, Eva Johansson, Tiantang Dong, Haimo Liu, Laust B Johnsen, Søren Lund, L. Anders Svensson, Haisun Zhu, Nidhin Thomas, Zhiru Yang, Henrik Østergaard
Efficient identification of epitopes is crucial for drug discovery and design as it enables the selection of optimal epitopes, expansion of lead antibody diversity, and verification of binding interface. Although high resolution low throughput method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::181c9655c5c7af86dfc74b699bfae00e
https://doi.org/10.1101/2023.04.04.535514
https://doi.org/10.1101/2023.04.04.535514
Autor:
Mihail Anton, Eivind Almaas, Rui Benfeitas, Sara Benito-Vaquerizo, Lars M. Blank, Andreas Dräger, John M. Hancock, Cheewin Kittikunapong, Matthias König, Feiran Li, Ulf W. Liebal, Hongzhong Lu, Hongwu Ma, Radhakrishnan Mahadevan, Adil Mardinoglu, Jens Nielsen, Juan Nogales, Marco Pagni, Jason A. Papin, Kiran Raosaheb Patil, Nathan D. Price, Jonathan L. Robinson, Benjamín J. Sánchez, Maria Suarez-Diez, Snorre Sulheim, L. Thomas Svensson, Bas Teusink, Wanwipa Vongsangnak, Hao Wang, Ahmad A. Zeidan, Eduard J. Kerkhoven
The field of metabolic modelling at the genomescale continues to grow with more models being created and curated. This comes with an increasing demand for adopting common principles regarding transparency and versioning, in addition to standardisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e77452cf0848a5f515f35c925440103
https://doi.org/10.1101/2023.03.21.512712
https://doi.org/10.1101/2023.03.21.512712
Autor:
Shamsudeen Umar Dandare, Maria Håkansson, L. Anders Svensson, David J. Timson, Christopher C. R. Allen
Publikováno v:
Dandare, S U, Håkansson, M, Svensson, L A, Timson, D J & Allen, C C R 2022, ' Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil ', Acta crystallographica. Section F, Structural biology communications, vol. 78, no. 4, pp. 161-169 . https://doi.org/10.1107/S2053230X22002345
Salicylaldehyde dehydrogenase (SALD) catalyses the last reaction in the upper pathway of naphthalene degradation: the oxidation of salicylaldehyde to salicylate. This enzyme has been isolated and studied from a few organisms that belong to the betapr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ff41e186d5c8ad1167ba11ff486a7e
https://doi.org/10.1107/s2053230x22002345
https://doi.org/10.1107/s2053230x22002345
Autor:
A I Abushouk, O Abdelfattah, A Saad, M M Gad, G W Reed, R Puri, J Yun, P R Vargo, A Weiss, D Burns, Z Popovic, S C Harb, A Krishnaswamy, L G Svensson, S R Kapadia
Publikováno v:
European Heart Journal. 42
Background Clinical studies have shown promising early outcomes for valve-in-valve transcatheter aortic valve implantation (ViV-TAVI); however, the late outcomes of this procedure remain under-investigated. Purpose We performed the present analysis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04aec42ab2129b8b8bdb539d5a234e4d
https://doi.org/10.1093/eurheartj/ehab724.2200
https://doi.org/10.1093/eurheartj/ehab724.2200
Autor:
H Lak, Y Sammour, S Chawla, R D Gajulapalli, A Kumar, P Parikh, L G Svensson, S Harb, K Tarakji, O Wazni, G W Reed, R Puri, A Krishnaswamy, S Kapadia
Publikováno v:
European Heart Journal. 42
Background Data regarding the impact of pacing on outcomes after transcatheter aortic valve replacement (TAVR) is evolving especially with regards to pre-existing PPM. We examined the impact of new and prior PPM on clinical and hemodynamic outcomes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2baaf338574675bc924a69625d244a6
https://doi.org/10.1093/eurheartj/ehab724.2180
https://doi.org/10.1093/eurheartj/ehab724.2180
Autor:
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Publikováno v:
Communications biology. 5(1)
Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd78f72ee93c60220e912ea248c2954b
https://pubmed.ncbi.nlm.nih.gov/35440683
https://pubmed.ncbi.nlm.nih.gov/35440683