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Autor: Michael L. B. Styles

Publikováno v: Plant Cell, Tissue and Organ Culture. 70:23-26

The advances in the biotechnology industry, and in biosciences research are impressive by any measure, but it is not sufficient just to continue to make spectacular scientific breakthroughs. It is important that the general public is assisted to keep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e11df9540b078210593505991a84d9ec
https://doi.org/10.1023/a:1016044806450

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The role of secretory phospholipase A2 in acute chest syndrome

Autor: F A, Kuypers, L A, Styles

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France). 50(1)

Acute chest syndrome (ACS) is the leading cause of death in sickle cell disease. Severe ACS often develops in the course of a vasoocclusive crisis (VOC), and frequently involves pulmonary fat embolism. Secretory phospholipase A2 (sPLA2), a potent inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e51ae96738f729a36d923fc2bedf7fd
https://pubmed.ncbi.nlm.nih.gov/15040432

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Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease

Autor: C R, Morris, F A, Kuypers, S, Larkin, N, Sweeters, J, Simon, E P, Vichinsky, L A, Styles

Publikováno v: British journal of haematology. 111(2)

To determine the effects of L-arginine (L-Arg) supplementation on nitric oxide metabolite (NOx) production, oral L-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69b05a4130fb81fbe2cf0eea88b91c16
https://pubmed.ncbi.nlm.nih.gov/11122090

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Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease

Autor: L A, Styles, A J, Aarsman, E P, Vichinsky, F A, Kuypers

Publikováno v: Blood. 96(9)

Acute chest syndrome (ACS) is the leading cause of death in sickle cell disease. Severe ACS often develops in the course of a vaso-occlusive crisis (VOC), but currently there are no predictors for its development. Secretory phospholipase A(2) (sPLA(2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0835ab3e9a31a43dec93ff33f1afcdb
https://pubmed.ncbi.nlm.nih.gov/11050014

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Whole blood tissue factor procoagulant activity is elevated in patients with sickle cell disease

Autor: N S, Key, A, Slungaard, L, Dandelet, S C, Nelson, C, Moertel, L A, Styles, F A, Kuypers, R R, Bach

Publikováno v: Blood. 91(11)

We developed a simple assay for the measurement of tissue factor procoagulant activity (TF PCA) in whole blood samples that avoids the need for mononuclear cell isolation. This method combines convenience of sample collection and processing with a hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6aee1121230014fe2e30df950e5e8ff
https://pubmed.ncbi.nlm.nih.gov/9596669

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Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea

Autor: L A, Styles, B, Lubin, E, Vichinsky, S, Lawrence, M, Hua, S, Test, F, Kuypers

Publikováno v: Blood. 89(7)

Sickle cell disease (SCD) is characterized by repeated vaso-occlusive events, which result in substantial morbidity. Abnormal adhesion of sickle red blood cells (RBC) to the vascular endothelium is postulated to play a role in the pathogenesis of vas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe37401e1529c7e8f46d8c94dba1130c
https://pubmed.ncbi.nlm.nih.gov/9116302

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Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease

Autor: E P, Vichinsky, L A, Styles, L H, Colangelo, E C, Wright, O, Castro, B, Nickerson

Publikováno v: Blood. 89(5)

Acute chest syndrome (ACS) is an important cause of morbidity and mortality in sickle cell disease (SCD). Previous studies reported conflicting pictures of ACS making therapeutic interventions difficult. The Cooperative Study of Sickle Cell Disease p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa71e394296e71af07881ad144dd2f03
https://pubmed.ncbi.nlm.nih.gov/9057664

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Core decompression in avascular necrosis of the hip in sickle-cell disease

Autor: L A, Styles, E P, Vichinsky

Publikováno v: American journal of hematology. 52(2)

Sickle-cell disease (SCD) is the most common cause of avascular necrosis (AVN) of the hip in childhood. It results in significant physical impairment and chronic pain, and often progresses to require hip replacement. Conservative therapy is ineffecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51fe5fa861805c9905072c51adaaa29e
https://pubmed.ncbi.nlm.nih.gov/8638629

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Phospholipase A2 levels in acute chest syndrome of sickle cell disease

Autor: L A, Styles, C G, Schalkwijk, A J, Aarsman, E P, Vichinsky, B H, Lubin, F A, Kuypers

Publikováno v: Blood. 87(6)

Acute chest syndrome (ACS) is associated with significant morbidity and is the leading cause of death in patients with sickle cell disease (SCD). Recent reports suggest that bone marrow fat embolism can be detected in many cases of severe ACS. Secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d82b07f763232b9dd040b271c964f82b
https://pubmed.ncbi.nlm.nih.gov/8630425

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