Differential transcriptome regulation by 3,5-T2 and 3′,3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia

Autor: N. Buisine, Verónica Jiménez-Jacinto, A. Olvera, Alejandro Sanchez-Flores, L. M. Sachs, Christopher J. Martyniuk, Aurea Orozco

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.15043. ⟨10.1038/s41598-017-14913-9⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Although 3,5,3′-triiodothyronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can also regulate transcriptional networks.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::637edaaf57b39832bf656ef66b77444d
https://doi.org/10.1038/s41598-017-14913-9

CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype

Autor: Walter E. Finkbeiner, L. A. Sachs, Horst Fischer, Jonathan Widdicombe, Beate Illek

Using cell culture models, we have investigated the relative importance of cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CaCC) in Cl secretion by mucous and serous cells of human airway glands. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad31b1a503554f6fed33c2069683d93
https://europepmc.org/articles/PMC2957417/

Effects of media on differentiation of cultured human tracheal epithelium

Autor: L A, Sachs, W E, Finkbeiner, J H, Widdicombe

Publikováno v: In vitro cellulardevelopmental biology. Animal. 39(1-2)

The purpose of the this study was to find media that supported high levels of differentiation in primary cultures of human tracheal epithelium. We tested six previously described, partially defined media and three nondefined media. Cells were grown w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::085a78e0eca73e2f7638be4c1cacc8af
https://pubmed.ncbi.nlm.nih.gov/12892528

Multiple stage-dependent roles for histone deacetylases during amphibian embryogenesis: implications for the involvement of extracellular matrix remodeling

Autor: S, Damjanovski, L M, Sachs, Y B, Shi

Publikováno v: The International journal of developmental biology. 44(7)

Histone acetylation has long been implicated in the regulation of gene expression. Recently, a number of histone acetyltransferase and histone deacetylase genes have been identified and cloned. Molecular studies have shown that these enzymes influenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27af9fee52dfbc9c0dde7bdaf3ac75d0
https://pubmed.ncbi.nlm.nih.gov/11128570

Declining class size and the decline in graduates choosing family medicine

Autor: L A Sachs, L C Bauer, Patrick J. Fahey

Publikováno v: Academic medicine : journal of the Association of American Medical Colleges. 67(10)

In light of the major concern about the marked decline in the numbers of graduates from U.S. medical schools who are entering family medicine, the authors analyzed the effect of declining class size on the numbers of graduates entering family medicin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d868c8879ec6377d865e1714a3de458
https://pubmed.ncbi.nlm.nih.gov/8466604