Výsledky vyhledávání

Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making

Autor: M, Rowland, L J, Lesko, A, Rostami-Hodjegan

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology

It is no coincidence that the reports of two meetings, one organized by the US Food and Drug Administration (FDA), in March 2014, and the other by the UK Medicines and Healthcare Products Regulatory (MHRA), in collaboration with ABPI (the Association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6669e45d5f701ec2ef7995e7cc991c4
https://pubmed.ncbi.nlm.nih.gov/26225258

Zobrazit plný text záznamu

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

Autor: Z, Wang, J C, Gorski, M A, Hamman, S M, Huang, L J, Lesko, S D, Hall

Publikováno v: Clinical pharmacology and therapeutics. 70(4)

St John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and herbal remedy that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. The effect of St John's wort on CYP acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c7370dd4b6f317d11c0814d7a0ce311
https://pubmed.ncbi.nlm.nih.gov/11673747

Zobrazit plný text záznamu

Variability in the bioavailability of phenytoin capsules in males and females

Autor: M C, Meyer, A B, Straughn, R M, Mhatre, V P, Shah, M L, Chen, R L, Williams, L J, Lesko

Publikováno v: Pharmaceutical research. 18(3)

To determine inter-lot and intra-subject variability in the bioavailability of the 100 mg extended phenytoin sodium capsules. In addition, to determine the effect of gender and menstrual cycle on phenytoin bioavailability.Three different lots of exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c95068c90f06cbf9be49e24adaaa09db
https://pubmed.ncbi.nlm.nih.gov/11442282

Zobrazit plný text záznamu

Pharmacokinetic/pharmacodynamic modeling in drug research and development

Autor: H, Derendorf, L J, Lesko, P, Chaikin, W A, Colburn, P, Lee, R, Miller, R, Powell, G, Rhodes, D, Stanski, J, Venitz

Publikováno v: Journal of clinical pharmacology. 40(12 Pt 2)

The two domains in clinical pharmacology dealing with optimizing dosing recommendations are pharmacokinetics and pharmacodynamics. However, the usefulness of these disciplines is limited if viewed in isolation. Pharmacokinetic/pharmacodynamic (PK/PD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0ccce75ead84703cb203363e08724f9
https://pubmed.ncbi.nlm.nih.gov/11185661

Zobrazit plný text záznamu

The effect of gelatin cross-linking on the bioequivalence of hard and soft gelatin acetaminophen capsules

Autor: M C, Meyer, A B, Straughn, R M, Mhatre, A, Hussain, V P, Shah, C B, Bottom, E T, Cole, L L, Lesko, H, Mallinowski, R L, Williams

Publikováno v: Pharmaceutical research. 17(8)

To determine if changes in the in vitro dissolution of hard and soft gelatin acetaminophen capsules, which result from gelatin crosslinking, are predictive of changes in the bioavailability of the capsules in humans.Both hard and soft gelatin capsule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7852819fbac7aeaf09ec24735b8d035d
https://pubmed.ncbi.nlm.nih.gov/11028942

Zobrazit plný text záznamu

The relative bioavailability and in vivo-in vitro correlations for four marketed carbamazepine tablets

Autor: M C, Meyer, A B, Straughn, R M, Mhatre, V P, Shah, R L, Williams, L J, Lesko

Publikováno v: Pharmaceutical research. 15(11)

To determine if three marketed generic carbamazepine tablets were bioequivalent to the innovator formulation, as well as to each other. In addition, to examine in vivo-in vitro relationships among the four formulations.Each formulation was given as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bfa3bc0a204bb79040e1d2eebdde5059
https://pubmed.ncbi.nlm.nih.gov/9834004

Zobrazit plný text záznamu

Lack of in vivo/in vitro correlations for 50 mg and 250 mg primidone tablets

Autor: M C, Meyer, A B, Straughn, R M, Mhatre, V P, Shah, R L, Williams, L J, Lesko

Publikováno v: Pharmaceutical research. 15(7)

To determine if large differences in the in vitro dissolution profiles for primidone tablets would result in significant bioavailability differences.Two separate bioavailability studies were conducted. The first study used 18 healthy subjects and com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce429e816b1fa84070f89a856822b6db
https://pubmed.ncbi.nlm.nih.gov/9688064

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání