Zobrazeno 1 - 10
of 28
pro vyhledávání: '"L A, Dethloff"'
Autor:
James Herman, E. J. Mcguire, Hiroshi Masuda, L. A. Dethloff, F. A. de la Iglesia, Kathleen M. Walsh, A. W. Gough, R. F. Parker
Publikováno v:
Toxicological Sciences. 68:226-236
Carcinogenic potential of the thiazolidinedione antidiabetic troglitazone was assessed in 104-week studies in mice and rats. Mice were given 50, 400, or 800 mg/kg, male rats 100, 400, or 800 mg/kg, and female rats 25, 50, or 200 mg/kg. Vehicle and pl
Publikováno v:
Toxicologic Pathology. 25:441-448
Gastric effects of subchronic treatment with the cholecystokinin-B (CCK-B)/gastrin receptor antagonist CI-988 were investigated in cynomolgus monkeys. In preliminary range-finding studies, CI-988 was given orally to 1 monkey per sex for 14 days at do
Autor:
Donald G. Robertson, L. A. Dethloff, Narendra D. Lalwani, Felix A. de la Iglesia, Jeffrey R. Haskins
Publikováno v:
Toxicologic Pathology. 25:165-176
Peroxisome proliferators are believed to induce liver tumors in rodents due to sustained increase in cell proliferation and oxidative stress resulting from the induction of peroxisomal enzymes. The objective of this study was to conduct a sequential
Autor:
L. A. Dethloff, Alexander W. Gough, Michael J. Graziano, Edwin Goldenthal, Felix A. de la Iglesia
Publikováno v:
Human & Experimental Toxicology. 15:335-348
1 Phenytoin is a hydantoin-type anticonvulsive agent used extensively for nearly sixty years in the prophylactic treatment of grand mal and psychomotor seizures. 2 Based upon somewhat contentious evidence of pheny toin-induced lymphoma in mice and up
Autor:
D. G. ROBERTSON, G. LOEWEN, K. M. WALSH, L. A. DETHLOFF, R. S. SIGLER, M. A. DOMINICK, E. R. URDA
Publikováno v:
Toxicological Sciences. 20:446-455
Autor:
L. A. Dethloff, John R. Watkins
Publikováno v:
Fundamental and Applied Toxicology. 19:6-14
Trimetrexate was administered to rats in an interrupted treatment regimen comparable to proposed human clinical treatment. Forty-five rats of each sex were dosed intravenously with trimetrexate at 0, 1, 10, or 30 mg/kg (0, 6, 60, or 180 mg/m2), once
Autor:
L. A. DETHLOFF, J. R. WATKINS
Publikováno v:
Toxicological Sciences. 19:6-14
Publikováno v:
International Journal of Radiation Biology. 60:657-675
The temporal patterns of several responses in the lungs of groups of rats administered two different thoracic doses of X-rays (7.5 and 15 Gy) were examined during a time frame within which radiation pneumonitis develops (1-13-week period) in order to
Autor:
Robert E. Sigler, L.L Bestervelt, L. A. Dethloff, Mark LaGattuta, Felix A. de la Iglesia, Steven J. Bulera, Bridget Barr
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 55(1)
Gabapentin induces pancreatic acinar cell tumors in rats through unknown, yet apparently nongenotoxic mechanisms. The primary objective of this study was to determine whether gabapentin acts as a tumor promoter by stimulating acinar cell proliferatio
Publikováno v:
Cellular signalling. 12(1)
Depending upon experimental model, the CCK-B/gastrin receptor ligand CI-988 exhibits either agonist or antagonist activity. To confirm that CI-988 behaves as an antagonist toward gastrin-stimulated growth, its effects on cell proliferation were inves