Zobrazeno 1 - 10
of 820
pro vyhledávání: '"L‐type calcium channels"'
Autor:
Natthaphat Siri-Angkul, Timothy J Kamp
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
L-type calcium channels (LTCCs), the major portal for Ca2+ entry into cardiomyocytes, are essential for excitation-contraction coupling and thus play a central role in regulating overall cardiac function. LTCC function is finely tuned by multiple sig
Externí odkaz:
https://doaj.org/article/25f1b019643e4eaaa276ee4da261b2d6
Autor:
Pietro Enea Lazzerini, Iacopo Bertolozzi, Alessandra Cartocci, Vamsi Krishna Murthy Ginjupalli, Pietro Alberto Teneggi, Davide Pica, Giovanni Merico, Irene Bogazzi, Viola Salvini, Riccardo Accioli, Fabio Salvadori, Tommaso Marzotti, Gabriele Cevenini, Matteo Capecchi, Silvia Cantara, Anna Cantore, Maria Infantino, Stefania Bisogno, Francesco Finizola, Flavio D'ascenzi, Franco Laghi‐Pasini, Maurizio Acampa, Pier Leopoldo Capecchi, Mohamed Boutjdir
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Background Advanced atrioventricular block (AVB), that is, higher than second‐degree Mobitz‐1, is an abnormal finding in athletes. Despite intensive investigation, in several cases the pathogenesis remains unknown, but frequently pacemaker implan
Externí odkaz:
https://doaj.org/article/bc1986338c414b4ca36d8b1371125126
Autor:
Hongya Gan, Huili Lan, Zhiqin Hu, Bingqi Zhu, Ling Sun, Yan Jiang, Lixiang Wu, Jing Liu, Zhishan Ding, Xiaoqing Ye
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 269, Iss , Pp 115772- (2024)
Triclosan (TCS) is a broad-spectrum antibacterial chemical widely presents in people’s daily lives. Epidemiological studies have revealed that TCS exposure may affect female puberty development. However, the developmental toxicity after low-dose TC
Externí odkaz:
https://doaj.org/article/4e3057e707eb43bf9244219d0091f50e
Autor:
Thomas Heigl, Michael A. Netzer, Lucia Zanetti, Matthias Ganglberger, Monica L. Fernández-Quintero, Alexandra Koschak
Publikováno v:
Channels, Vol 17, Iss 1 (2023)
ABSTRACTCav1.4 L-type calcium channels are predominantly expressed at the photoreceptor terminals and in bipolar cells, mediating neurotransmitter release. Mutations in its gene, CACNA1F, can cause congenital stationary night-blindness type 2 (CSNB2)
Externí odkaz:
https://doaj.org/article/ef2b99a0abab4d838bb79811b9811fd5
Autor:
Barbora Waclawiková, Paulo Cesar Telles de Souza, Markus Schwalbe, Constantinos G. Neochoritis, Warner Hoornenborg, Sieger A. Nelemans, Siewert J. Marrink, Sahar El Aidy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTIntestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its
Externí odkaz:
https://doaj.org/article/bfc4e2f6d78e4fee9419d2cb3d2f3e4a
Publikováno v:
Chemistry, Vol 5, Iss 2, Pp 713-719 (2023)
Molecular interactions of 4-diphenylmethoxy-1-methylpiperidine derivatives with the calcium channel CaV1.1 (pdb:6JP5) are described. All the compounds tested, previously shown to inhibit adrenergic vascular contractions, display similar binding energ
Externí odkaz:
https://doaj.org/article/42886a10a6774c73b79f9cded8d26794
Autor:
Szymon Chowański, Magdalena Winkiel, Monika Szymczak-Cendlak, Paweł Marciniak, Dominika Mańczak, Karolina Walkowiak-Nowicka, Marta Spochacz, Sabino A. Bufo, Laura Scrano, Zbigniew Adamski
Publikováno v:
Pharmaceutical Biology, Vol 60, Iss 1, Pp 1317-1330 (2022)
Context Solanaceae glycoalkaloids (SGAs) possess cardiomodulatory activity.Objective This study investigated the potential interaction between verapamil and glycoalkaloids.Material and methods The cardioactivity of verapamil and glycoalkaloids (α-so
Externí odkaz:
https://doaj.org/article/a32aa6cc4abb492d9a52d0cef8adb967
Autor:
Kwun Nok Mimi Man, Peter Bartels, Peter B Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Sheng-Yang Ho, Madeline Nieves-Cintron, Manuel F Navedo, Mary C Horne, Johannes W Hell
Publikováno v:
eLife, Vol 12 (2023)
The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca2+ channel (LTCC) CaV1.2 as a principal target for Gq-coupled α1-adrenergic receptors (ARs). α1AR signaling incr
Externí odkaz:
https://doaj.org/article/3817fb9d55da497485e8cde29a419fb9
Autor:
Holger Schneider
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/27d670b65bcf40c3b64e92268aee3543
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