Zobrazeno 1 - 10
of 12 156
pro vyhledávání: '"L‐dopa"'
Autor:
Daisuke Hatta, Shiho Makiya, Kaito Kanamoto, Kaori Watanabe, Yuki Fuchigami, Shigeru Kawakami, Akira Kinoshita, Koh‐Ichiro Yoshiura, Naohiro Kurotaki, Keiro Shirotani, Nobuhisa Iwata
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 4, Pp 829-834 (2024)
Abstract Mutations in proline‐rich transmembrane protein 2 (PRRT2) cause paroxysmal kinesigenic dyskinesia (PKD). Recently, we reported that a Prrt2 mutation exacerbated L‐dopa‐induced motor deficits in mice, suggesting that the basal ganglia m
Externí odkaz:
https://doaj.org/article/a06d3827f97847b48d81d98845aa6f20
Autor:
Kyle S. Chan, Nitika Aggarwal, Shannon Lawson, Nick Boucher, Mathew W. MacCumber, Jeremy A. Lavine
Publikováno v:
Eye and Vision, Vol 11, Iss 1, Pp 1-6 (2024)
Abstract Background Geographic atrophy (GA) is a significant cause of vision loss in patients with age-related macular degeneration (AMD). Current treatments are limited to anti-complement drugs, which have limited efficacy to delay progression with
Externí odkaz:
https://doaj.org/article/ea4b171ff11e49d490f7343f69eef9cb
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 939-53 (2024)
Parkinson’s disease (PD) is primarily known as a motor disorder; however, its debilitating non-motor symptoms have a significant impact on patients’ quality of life. The current standard treatment, l-DOPA, is used to relieve motor symptoms, but p
Externí odkaz:
https://doaj.org/article/a57df5f84b734b09b9c42a8f8adfa887
Autor:
Joon-Pyo Hong, Sooan Shin, So Hyeon Chung, Myung-chul Song, Jin-gon Shim, Yoongeun Kim, Bombi Lee, Mijung Yeom, Hi-Joon Park, Kwang‑Hwan Jung, Jongki Hong, Dae-Hyun Hahm
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Despite the intensive research on gut microbiome-associated diseases over the past 20 years, pharmacological methods for effectively eliminating pathobionts remain unsatisfactory. This study investigated the therapeutic potential of bacterio
Externí odkaz:
https://doaj.org/article/38f670e56fb244c9b078ce27008832b6
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Enzymes with high catalytic activity and stability are essential for industrial production, yet most natural enzymes do not meet these requirements. Therefore, efficient strategies for enzyme engineering are crucial. In this study, we develo
Externí odkaz:
https://doaj.org/article/8065b17ca6de470183777659088c8d18
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 10, Pp 1524-1527 (2024)
ABSTRACT Diabetic striatopathy, a rare hyperglycemia complication, is characterized by chorea/ballism and striatal anomalies on neuroimaging, usually managed with glycemic control and haloperidol. However, practical strategies for haloperidol‐resis
Externí odkaz:
https://doaj.org/article/3b2bc1dd56624aaca4871c579edae53a
Autor:
Zahra Taheri, Maryam Kazemi, Bahman Khalvati, Farshad Safari, Samira Hossaini Alhashemi, Fatemeh Ahmadi, Ali Dehshahri
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract High molecular weight polyethylenimine (HMW PEI; branched 25 kDa PEI) has been widely investigated for gene delivery due to its high transfection efficiency. However, the toxicity and lack of targeting to specific cells have limited its clin
Externí odkaz:
https://doaj.org/article/7b63b85f0e8542b1871ba9ccc0960cb6
Autor:
Yesim Yeni, Sıdıka Genc, Muhammed Sait Ertugrul, Hayrunnisa Nadaroglu, Arzu Gezer, Ali Sefa Mendil, Ahmet Hacımuftuoglu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Parkinson’s disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such
Externí odkaz:
https://doaj.org/article/31e06e2d52344af390a72f5dd28bd883
Publikováno v:
BMC Medical Genomics, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Background Chronic kidney disease (CKD) and hypertension are chronic diseases affecting a large portion of the population frequently coexistent and interdependent. The inability to produce/use adequate renal dopamine may contribute to the de
Externí odkaz:
https://doaj.org/article/ddcc959c551e492e81bc1d13cb35287a
Autor:
Hyun-ju Lee, JinHan Nam, Jeong-Woo Hwang, Jin-Hee Park, Yoo Joo Jeong, Ji-Yeong Jang, Su-Jeong Kim, A-Ran Jo, Hyang-Sook Hoe
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Dopamine plays important roles in cognitive function and inflammation and therefore is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Drugs that increase or maintain dopamine levels in the bra
Externí odkaz:
https://doaj.org/article/13e1166c72ae494aa46d707afb237d9c