Can TiC nanoparticles produce toxicity in oral administration to rats?

Autor: Julie Laloy, Omar Lozano, Lütfiye Alpan, Jorge Mejia, Olivier Toussaint, Bernard Masereel, Jean-Michel Dogné, Stéphane Lucas

Publikováno v: Toxicology Reports, Vol 1, Iss C, Pp 172-187 (2014)

Background: Titanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC

Externí odkaz: https://doaj.org/article/87fe9624b0be426ebfb9bf4566558389

Importance of measuring pharmacologically active metabolites of edoxaban:development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method

Autor: Philippe Devel, Lütfiye Alpan, Romain Siriez, Jean-Michel Dogné, Kossay Elasaad, Julie Laloy, Jonathan Douxfils

Publikováno v: Siriez, R, Alpan, L, Elasaad, K, Devel, P, Laloy, J, Dogne, J-M & Douxfils, J 2020, ' Importance of measuring pharmacologically active metabolites of edoxaban : development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method ', Journal of Thrombosis and Thrombolysis, vol. 49, no. 3, pp. 395-403 . https://doi.org/10.1007/s11239-019-02030-5

Although DOACs do not require regular measurements of their blood concentrations, clinical situations may require an assessment of their concentration. Among the factor Xa inhibitors, edoxaban is the only compound for which some metabolites (e.g. edo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dead061928fc6f2031a201f6fe3b3dbf
https://pure.unamur.be/ws/files/41509105/Edoxaban_measurement_241219.pdf

Prospective and comparative study of paroxysmal nocturnal hemoglobinuria patients treated or not by eculizumab:Focus on platelet extracellular vesicles

Autor: Christian Chatelain, Bernard Chatelain, Benoît Bihin, Nicolas Bailly, Jonathan Douxfils, Lütfiye Alpan, Bérangère Devalet, Damien Gheldof, Adeline Wannez, Jean-Michel Dogné, François Mullier

Publikováno v: Devalet, B, Wannez, A, Bailly, N, Alpan, L, Gheldof, D, Douxfils, J, Bihin, B, Chatelain, B, Dogné, J-M, Chatelain, C & Mullier, F 2019, ' Prospective and comparative study of paroxysmal nocturnal hemoglobinuria patients treated or not by eculizumab : Focus on platelet extracellular vesicles ', Medicine (Mumbai): analytical reviews of general medicine, neurology, psychiatry, dermatology and pediatrics, vol. 98, no. 27, pp. e16164 . https://doi.org/10.1097/MD.0000000000016164
Medicine
Medicine, Vol. 98, no. 27, p. e16164 [1-8] (2019)

Thrombosis are severe complications of paroxysmal nocturnal hemoglobinuria (PNH), effectively reduced by eculizumab. Extracellular vesicles (EVs) may play a central role. The objective of this study was to assess the procoagulant activity of plasma i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7dfddadc43392bb80e7c86ddebc1f6
https://pure.unamur.be/ws/files/40063344/DevaletMedicine2019.pdf

Characterization of core/shell Cu/Ag nanopowders synthesized by electrochemistry and assessment of their impact on hemolysis, platelet aggregation, and coagulation on human blood for potential wound dressing use

Autor: Patrick Fricoteaux, Lütfiye Alpan, Valérie Mancier, Julie Laloy, Céline Rousse, Jorge Mejia, Samuel Levi, Jean-Michel Dogné, Hélène Haguet, Stéphane Lucas

Publikováno v: Journal of Nanoparticle Research
Journal of Nanoparticle Research, Springer Verlag, 2017, 19 (8), ⟨10.1007/s11051-017-3937-0⟩

Copper/silver core/shell nanopowders with different metal ratio have been elaborated by electrochemistry (ultrasound-assisted electrolysis followed by a displacement reaction). Characterization was performed by several methods (X-ray diffraction, sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da91a23bc3d0f49a778f4f7d57437ff5
https://doi.org/10.1007/s11051-017-3937-0

Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists

Autor: Sylvie-Mireille Bambi-Nyanguile, Julien Hanson, Jean-Michel Dogné, Bernard Pirotte, Philippe Kolh, Lütfiye Alpan, Annie Ooms

Publikováno v: European Journal of Medicinal Chemistry. 65:32-40

New series of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas were synthesized and evaluated as thromboxane A2 receptor (TP receptor) antagonists. A functional pharmacological test was used, which consisted of measuring the inhibition of int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e20ff78644929d988ec8f9a6c8d05bc
https://doi.org/10.1016/j.ejmech.2013.04.033