Application of biorelevant in vitro assays for the assessment and optimization of ASD-based formulations for pediatric patients

Autor: Niessen, Janis, López Mármol, Álvaro, Ismail, Ruba, Schiele, Julia T., Rau, Karola, Wahl, Andrea, Sauer, Kerstin, Heinzerling, Oliver, Breitkreutz, Jörg, Koziolek, Mirko

Publikováno v: In European Journal of Pharmaceutics and Biopharmaceutics April 2023 185:13-27

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media.

Autor: Ye, Dong¹ (AUTHOR) dong.ye@abbvie.com, López Mármol, Álvaro² (AUTHOR) alvaro.lopezmarmol@abbvie.com, Lenz, Verena² (AUTHOR) verena.lenz@abbvie.com, Muschong, Patricia¹ (AUTHOR) patricia.muschong@abbvie.com, Wilhelm-Alkubaisi, Anita¹ (AUTHOR) anita.wilhelm-alkubaisi@abbvie.com, Weinheimer, Manuel¹ (AUTHOR) manuel.weinheimer@abbvie.com, Koziolek, Mirko² (AUTHOR) mirko.koziolek@abbvie.com, Sauer, Kerstin A.² (AUTHOR) kerstin.sauer@abbvie.com, Laplanche, Loic¹ (AUTHOR) loic.laplanche@abbvie.com, Mezler, Mario¹ (AUTHOR) mario.mezler@abbvie.com

Publikováno v: Pharmaceutics. Apr2022, Vol. 14 Issue 4, pN.PAG-N.PAG. 16p.

PROTAC-mediated crosstalk between E3 ligases.

Autor: Steinebach, Christian, Kehm, Hannes, Lindner, Stefanie, Vu, Lan Phuong, Köpff, Simon, López Mármol, Álvaro, Weiler, Corinna, Wagner, Karl G., Reichenzeller, Michaela, Krönke, Jan, Gütschow, Michael

Publikováno v: Chemical Communications; 2/11/2019, Vol. 55 Issue 12, p1821-1824, 4p

Tracking the journey: Gastrointestinal transit and intraluminal pH dynamics in aging populations using wireless motility capsule.

Autor: Edwina AE; Gerontology and Geriatrics, Department of Public Health and Primary Care, KU Leuven - University of Leuven, Leuven, Belgium., Koziolek M; NCE Drug Product Development, Development Sciences, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany., Steenackers N; Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Vanuytsel T; Translational Research Center for Gastrointestinal Disorders, TARGID, KU Leuven, Leuven, Belgium; Gastroenterology and Hepatology, University Hospitals Leuven Campus Gasthuisberg, Leuven, Belgium., López Mármol Á; NCE Drug Product Development, Development Sciences, AbbVie Deutschland GmbH & Co. KG, Ludwigshafen am Rhein, Germany., Matthys C; Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium; Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium., Dreesen E; Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium., Van der Linden L; Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium., Spriet I; Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven - University of Leuven, Leuven, Belgium; Pharmacy Department, University Hospitals Leuven, Leuven, Belgium., Tournoy J; Gerontology and Geriatrics, Department of Public Health and Primary Care, KU Leuven - University of Leuven, Leuven, Belgium; Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium. Electronic address: elma.edwina@kuleuven.be.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2024 Dec 05; Vol. 669, pp. 125016. Date of Electronic Publication: 2024 Dec 05.