Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification

Autor: Mária Pukáncsik, Petra Molnár, Ágnes Orbán, Ádám Butykai, Lívia Marton, István Kézsmárki, Beáta G. Vértessy, Mohd Kamil, Amanah Abraham, Ahmed S. I. Aly

Publikováno v: Biomolecules, Vol 9, Iss 10, p 579 (2019)

The rotating-crystal magneto-optical diagnostic (RMOD) technique was developed as a sensitive and rapid platform for malaria diagnosis. Herein, we report a detailed in vivo assessment of the synchronized Plasmodium vinckei lentum strain blood-stage i

Externí odkaz: https://doaj.org/article/c17b0b73491648dca49baa658e0debaf

Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase.

Autor: Lívia Marton, Gergely N Nagy, Olivér Ozohanics, Anikó Lábas, Balázs Krámos, Julianna Oláh, Károly Vékey, Beáta G Vértessy

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129632 (2015)

Control and elimination of malaria still represents a major public health challenge. Emerging parasite resistance to current therapies urges development of antimalarials with novel mechanism of action. Phospholipid biosynthesis of the Plasmodium para

Externí odkaz: https://doaj.org/article/cfe84253e72e440abf15cfd9a279ed69

Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin

Autor: Petra Molnár, István Kézsmárki, Beáta G. Vértessy, Ágnes Orbán, Ádám Butykai, Réka Babai, Richard Izrael, Stephan Karl, Lívia Marton

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)

Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2658afabe2d4c254905ad0976459e45f
http://europepmc.org/articles/PMC7441145

Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification

Autor: Mohd Kamil, Petra Molnár, István Kézsmárki, Mária Pukáncsik, Ahmed S. I. Aly, Ádám Butykai, Beáta G. Vértessy, Lívia Marton, Ágnes Orbán, Amanah Abraham

Publikováno v: Biomolecules
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 579 (2019)

The rotating-crystal magneto-optical diagnostic (RMOD) technique was developed as a sensitive and rapid platform for malaria diagnosis. Herein, we report a detailed in vivo assessment of the synchronized Plasmodium vinckei lentum strain blood-stage i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5a9707d131ed13b17bff32cb907827
https://openaccess.bezmialem.edu.tr/handle/20.500.12645/13222

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

Autor: Gergely N. Nagy, Rachel Cerdan, Yinshan Yang, François Hoh, Jean-François Guichou, Henri Vial, Fanni Hajdú, Beáta G. Vértessy, Ewelina Guca, Lívia Marton, Richard Izrael

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
'Scientific Reports ', vol: 8, pages: 11215-1-11215-13 (2018)
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-29500-9⟩

The development of the malaria parasite, Plasmodium falciparum, in the human erythrocyte, relies on phospholipid metabolism to fulfil the massive need for membrane biogenesis. Phosphatidylcholine (PC) is the most abundant phospholipid in Plasmodium m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ec05d8dbd2d41ca90041adffa6d92a
https://doi.org/10.1038/s41598-018-29500-9