Improved dissolution and micromeritic properties of naproxen from spherical agglomerates: preparation, in vitro and in vivo characterization

Autor: R Nagaraju, Grandhi Madhuri, Poreddy Srikanth Reddy, Damineni Saritha, Penjuri Subhash Chandra Bose

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Volume: 48, Issue: 4, Pages: 667-676, Published: DEC 2012
Brazilian Journal of Pharmaceutical Sciences; Vol. 48 No. 4 (2012); 683-690
Brazilian Journal of Pharmaceutical Sciences; Vol. 48 Núm. 4 (2012); 683-690
Brazilian Journal of Pharmaceutical Sciences; v. 48 n. 4 (2012); 683-690
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP
Brazilian Journal of Pharmaceutical Sciences, Vol 48, Iss 4, Pp 683-690 (2012)

Naproxen, an anti-inflammatory drug, exhibits poor aqueous solubility, which limits the pharmacological effects. The present work was carried out to study the effect of agglomeration on micromeritic properties and dissolution. Naproxen agglomerates w

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