An association study of FOXO3 variant and longevity

Autor: Geralda Gillian Silva-Sena, Daniela Camporez, Lígia Ramos dos Santos, Aline Sesana da Silva, Lúcia Helena Sagrillo Pimassoni, Alessandra Tieppo, Maria do Carmo Pimentel Batitucci, Renato Lírio Morelato, Flavia de Paula

Publikováno v: Genetics and Molecular Biology, Iss 0 (2018)

Abstract Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between env

Externí odkaz: https://doaj.org/article/e8f1b7db281a44ed95b1e4cbbad720a7

[PROVISIONAL] The combined risk effect among BIN1, CLU and APOE genes in Alzheimer’s disease

Autor: Lígia Ramos dos Santos, Jucimara Ferreira Figueiredo Almeida, Lúcia Helena Sagrillo Pimassoni, Renato Lírio Morelato, Flavia de Paula

Publikováno v: Genetics and Molecular Biology

Abstract Genome-wide associations studies (GWAS) have been detecting new variants associated with late-onset of Alzheimer’s disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU rs3764650 ABCA7 unco

Externí odkaz: https://doaj.org/article/ca2bdfdedc3542f4a3ea6f28319d2df2

Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models

Autor: Lígia Ramos dos Santos, Frédéric Checler, Aurore Bernardin, Lila Rouland, Guidalberto Manfioletti, Cristine Alves da Costa, Ahmed Idbaih, Eric Duplan, Karen S. Katula

Publikováno v: Theranostics
Theranostics, 2021, 11 (20), pp.10047-10063. ⟨10.7150/thno.57549⟩
Theranostics, Ivyspring International Publisher, 2021, 11 (20), pp.10047-10063. ⟨10.7150/thno.57549⟩

International audience; Parkin (PK) is an E3-ligase harboring tumor suppressor properties that has been associated to various cancer types including glioblastoma (GBM). However, PK is also a transcription factor (TF), the contribution of which to GBM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d7de30586c92015ed01443f5c96678
https://hal.sorbonne-universite.fr/hal-03456882

The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer’s disease

Autor: Lúcia Helena Sagrillo Pimassoni, Jucimara Ferreira Figueiredo Almeida, Renato Lírio Morelato, Lígia Ramos dos Santos, Flavia de Paula

Publikováno v: Genetics and Molecular Biology v.43 n.1 2020
Genetics and Molecular Biology
Sociedade Brasileira de Genética (SBG)
instacron:SBG
Genetics and Molecular Biology, Volume: 43, Issue: 1, Article number: e20180320, Published: 16 MAR 2020

Genome-wide associations studies (GWAS) are detecting new variants associated with late-onset of Alzheimer’s disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU and rs3764650 ABCA7 uncovered by GW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e268f7e800f377b78980f61c1e420c71
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100113

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