Výsledky vyhledávání - "Lídia Mateo"

Akademický článek

Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in App NL-G-F , App NL-F , and 3xTg-AD mouse models

Autor: Eduardo Pauls, Sergi Bayod, Lídia Mateo, Víctor Alcalde, Teresa Juan-Blanco, Marta Sánchez-Soto, Takaomi C. Saido, Takashi Saito, Antoni Berrenguer-Llergo, Camille Stephan-Otto Attolini, Marina Gay, Eliandre de Oliveira, Miquel Duran-Frigola, Patrick Aloy

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-23 (2021)

Abstract Background In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Inde

Externí odkaz: https://doaj.org/article/2b157e83f6584ec39487fe35e9934baf

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Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models

Publikováno v: Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-23 (2021)

Background In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are hardly effective. Indeed, the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d62c1e06337470304611e146605cc4a
https://doi.org/10.1186/s13073-021-00983-y

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Akademický článek

Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

Autor: Lidia Mateo, Miquel Duran-Frigola, Albert Gris-Oliver, Marta Palafox, Maurizio Scaltriti, Pedram Razavi, Sarat Chandarlapaty, Joaquin Arribas, Meritxell Bellet, Violeta Serra, Patrick Aloy

Publikováno v: Genome Medicine, Vol 12, Iss 1, Pp 1-23 (2020)

Abstract Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) network

Externí odkaz: https://doaj.org/article/8d63f66e5204442188fe04baf4456244

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Akademický článek

Exploring the OncoGenomic Landscape of cancer

Autor: Lidia Mateo, Oriol Guitart-Pla, Miquel Duran-Frigola, Patrick Aloy

Publikováno v: Genome Medicine, Vol 10, Iss 1, Pp 1-8 (2018)

Abstract Background The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients. A main current challenge is to find out reliable ways to extrapola

Externí odkaz: https://doaj.org/article/f1b96d1f25864c0f9283a4041ec3264f

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