Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress

Autor: Mariane Bertagnolli, Daniela R. Dartora, Pablo Lamata, Ernesto Zacur, Thuy-An Mai-Vo, Ying He, Léonie Beauchamp, Adam J. Lewandowski, Anik Cloutier, Megan R. Sutherland, Robson A.S. Santos, Anne Monique Nuyt

Publikováno v: Bertagnolli, M, Dartora, D R, Lamata, P, Zacur, E, Mai Vo, T-A, He, Y, Beauchamp, L, Lewandowski, A J, Cloutier, A, Sutherland, M R, Santos, R A S & Nuyt, A M 2022, ' Reshaping the preterm heart : Shifting cardiac renin-angiotensin system towards cardioprotection in rats exposed to neonatal high-oxygen stress ', Hypertension, vol. 79, no. 8, pp. 1789-1803 . https://doi.org/10.1161/HYPERTENSIONAHA.122.19115

Background: Approximately 10% of infants are born preterm. Preterm birth leads to short and long-term changes in cardiac shape and function. By using a rat model of neonatal high-oxygen (80%O 2 ) exposure, mimicking the premature hyperoxic transition

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https://pubmed.ncbi.nlm.nih.gov/35588210