Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Léo Ghemtio"'
Publikováno v:
Molecular Informatics. 42
Autor:
Jaakko Itkonen, Leo Ghemtio, Daniela Pellegrino, Pia J. Jokela (née Heinonen), Henri Xhaard, Marco G. Casteleijn
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1639 (2022)
Pharmaceutical proteins, compared to small molecular weight drugs, are relatively fragile molecules, thus necessitating monitoring protein unfolding and aggregation during production and post-marketing. Currently, many analytical techniques take offl
Externí odkaz:
https://doaj.org/article/927cd2094a154036a17e0b177537a3c5
Publikováno v:
Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Betulin derivatives have been proven effective in vitro against Leishmania donovani amastigotes, which cause visceral leishmaniasis. Identifying the molecular targets and molecular mechanisms underlying their action is a currently an unmet c
Externí odkaz:
https://doaj.org/article/21c7480e649348d38af3c4d5992e678f
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141943 (2015)
Externí odkaz:
https://doaj.org/article/90a76e99b7f8497292c42da7aab3b5b6
Autor:
Shafiul Haque, Dorota A Nawrot, Sami Alakurtti, Leo Ghemtio, Jari Yli-Kauhaluoma, Päivi Tammela
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102696 (2014)
Betulin (lup-20(29)-ene-3β, 28-diol) is a naturally occurring triterpene, which is found in substantial amounts from the outer bark of birch trees. A library of 51 structurally diverse semisynthetic betulin derivatives was screened against five bact
Externí odkaz:
https://doaj.org/article/fc5817bd3a1444539d9eefe420811408
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74758 (2013)
Volume of distribution and fraction unbound are two key parameters in pharmacokinetics. The fraction unbound describes the portion of free drug in plasma that may extravasate, while volume of distribution describes the tissue access and binding of a
Externí odkaz:
https://doaj.org/article/a34d729e187e42fab4695f93056af48a