Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Léanie Kleynhans"'
Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity
Autor:
Clare Eckold, Cassandra L. R. vanDoorn, Rovina Ruslami, Katharina Ronacher, Anca‐Lelia Riza, Suzanne vanVeen, Ji‐Sook Lee, Vinod Kumar, Sarah Kerry‐Barnard, Stephanus T. Malherbe, Léanie Kleynhans, Kim Stanley, Simone A. Joosten, Julia A Critchley, Philip C. Hill, Reinout vanCrevel, Cisca Wijmenga, Mariëlle C. Haks, Mihai Ioana, Bachti Alisjahbana, Gerhard Walzl, Tom H. M. Ottenhoff, Hazel M. Dockrell, Eleonora Vianello, Jacqueline M. Cliff, the TANDEM Consortium$
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Background People with diabetes are more likely to develop tuberculosis (TB) and to have poor TB‐treatment outcomes than those without. We previously showed that blood transcriptomes in people with TB‐diabetes (TB‐DM) co‐morbidity ha
Externí odkaz:
https://doaj.org/article/229588c3fbff41bc8ad7133cef9a8c93
Autor:
Christina Meiring, Haiko Schurz, Paul van Helden, Eileen Hoal, Gerard Tromp, Craig Kinnear, Léanie Kleynhans, Brigitte Glanzmann, Louis van Schalkwyk, Michele Miller, Marlo Möller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract African wild dogs (Lycaon pictus) have undergone severe population reductions and are listed as endangered on the International Union for Conservation of Nature Red List. Small, isolated populations have the potential to suffer from threats
Externí odkaz:
https://doaj.org/article/117f7faaf05f4239a7220f8cae8d3adc
Autor:
Cassandra L.R. van Doorn, Clare Eckold, Katharina Ronacher, Rovina Ruslami, Suzanne van Veen, Ji-Sook Lee, Vinod Kumar, Sarah Kerry-Barnard, Stephanus T. Malherbe, Léanie Kleynhans, Kim Stanley, Philip C. Hill, Simone A. Joosten, Reinout van Crevel, Cisca Wijmenga, Julia A. Critchley, Gerhard Walzl, Bachti Alisjahbana, Mariëlle C. Haks, Hazel M. Dockrell, Tom H.M. Ottenhoff, Eleonora Vianello, Jacqueline M. Cliff
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104173- (2022)
Summary: Background: Globally, the tuberculosis (TB) treatment success rate is approximately 85%, with treatment failure, relapse and death occurring in a significant proportion of pulmonary TB patients. Treatment success is lower among people with d
Externí odkaz:
https://doaj.org/article/d8a5f598ec4c4e9383b52b8fc1ff3690
Autor:
Charlene Clarke, Katrin Smith, Samantha J. Goldswain, Christopher Helm, David V. Cooper, Tanya J. Kerr, Léanie Kleynhans, Paul D. van Helden, Robin M. Warren, Michele A. Miller, Wynand J. Goosen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
Abstract Mycobacterium bovis is the causative agent of bovine tuberculosis (bTB) in wildlife. Confirmation of M. bovis infection relies on mycobacterial culture, which is time-consuming. Collection and transportation of infectious material also pose
Externí odkaz:
https://doaj.org/article/6e278a5b15124511bbb3bddac57174b5
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The role of the endocrine system on the immune response, especially in the lung, remains poorly understood. Hormones play a crucial role in the development, homeostasis, metabolism, and response to the environment of cells and tissues. Major infectio
Externí odkaz:
https://doaj.org/article/abe04bd0ee774584aa4527eb7dbc9786
Autor:
Stuart Meier, James A Seddon, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G Loxton, Stephanus T Malherbe, Daniel E Zak, Ethan Thompson, Fergal J Duffy, Stefan H E Kaufmann, Tom H M Ottenhoff, Thomas J Scriba, Sara Suliman, Jayne S Sutherland, Jill Winter, Helena Kuivaniemi, Gerhard Walzl, Gerard Tromp, GC6-74 Consortium, Catalysis TB Biomarkers Consortium
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278295 (2022)
Mycobacterium tuberculosis (M.tb) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune responses have been implicated in driving the progression from infection to severe lung disease.
Externí odkaz:
https://doaj.org/article/a9c3c19a74ea47aa90537128b591d9f8
Autor:
Michele A. Miller, Tanya J. Kerr, Candice R. de Waal, Wynand J. Goosen, Elizabeth M. Streicher, Guy Hausler, Leana Rossouw, Tebogo Manamela, Louis van Schalkwyk, Léanie Kleynhans, Robin Warren, Paul van Helden, Peter E. Buss
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 3, Pp 990-992 (2021)
Mycobacterium bovis infection in wildlife species occurs worldwide. However, few cases of M. bovis infection in captive elephants have been reported. We describe 2 incidental cases of bovine tuberculosis in free-ranging African elephants (Loxodonta a
Externí odkaz:
https://doaj.org/article/c532bd2771ad41d781bc3adc57ec09fa
Autor:
Wynand J. Goosen, Tanya J. Kerr, Léanie Kleynhans, Peter Buss, David Cooper, Robin M. Warren, Paul D. van Helden, Björn Schröder, Sven D. C. Parsons, Michele A. Miller
Publikováno v:
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-6 (2020)
Abstract Background Bovine tuberculosis and tuberculosis are chronic infectious diseases caused by the Mycobacterium tuberculosis complex members, Mycobacterium bovis and Mycobacterium tuberculosis, respectively. Infection with M. bovis and M. tuberc
Externí odkaz:
https://doaj.org/article/5be63ac8054b45c3bb7836c972bac939
Autor:
Charlene Clarke, Tanya J. Kerr, Robin M. Warren, Léanie Kleynhans, Michele A. Miller, Wynand J. Goosen
Publikováno v:
Microorganisms, Vol 10, Iss 9, p 1861 (2022)
Diagnosis of bovine tuberculosis (bTB) may be confounded by immunological cross-reactivity to Mycobacterium bovis antigens when animals are sensitised by certain nontuberculous mycobacteria (NTMs). Therefore, this study aimed to investigate NTM speci
Externí odkaz:
https://doaj.org/article/7f6bd9123d8a4d45a7bc4ac22b82c187
Autor:
Wynand J. Goosen, Charlene Clarke, Léanie Kleynhans, Tanya J. Kerr, Peter Buss, Michele A. Miller
Publikováno v:
Pathogens, Vol 11, Iss 6, p 709 (2022)
Since certain Mycobacterium tuberculosis complex (MTBC) members, such as M. bovis, are endemic in specific South African wildlife reserves and zoos, cases of clinically important nontuberculous mycobacteria (NTM) in wildlife may be neglected. Additio
Externí odkaz:
https://doaj.org/article/cad41029a54349afb4ec4921c24d872a