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Akademický článek

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons

Autor: Léa Tochon, Nadia Henkous, Morgane Besson, Uwe Maskos, Vincent David

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Genome wide association and animal studies have implicated genetic variations in CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5*nAChRs), as a risk factor for developing alcohol use disorders (AUDs). To un

Externí odkaz: https://doaj.org/article/7bbf04806c8b4a1b9c2c52ab1d484801

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Akademický článek

Chronic alcohol consumption shifts learning strategies and synaptic plasticity from hippocampus to striatum-dependent pathways

Autor: Léa Tochon, Rose-Marie Vouimba, Marc Corio, Nadia Henkous, Daniel Béracochéa, Jean-Louis Guillou, Vincent David

Publikováno v: Frontiers in Psychiatry, Vol 14 (2023)

IntroductionThe hippocampus and striatum have dissociable roles in memory and are necessary for spatial and procedural/cued learning, respectively. Emotionally charged, stressful events promote the use of striatal- over hippocampus-dependent learning

Externí odkaz: https://doaj.org/article/b87a3dc818a442af9d21aeda548e5d0f

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Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice

Autor: Alina Lakosa, Anaïs Rahimian, Flavio Tomasi, Fabio Marti, Lauren M. Reynolds, Léa Tochon, Vincent David, Anne Danckaert, Candice Canonne, Sylvana Tahraoui, Fabrice de Chaumont, Benoît Forget, Uwe Maskos, Morgane Besson

Publikováno v: Neuropsychopharmacology
Neuropsychopharmacology, 2023, ⟨10.1038/s41386-023-01563-x⟩

International audience; A link between gut dysbiosis and the pathogenesis of brain disorders has been identified. A role for gut bacteria in drug reward and addiction has been suggested but very few studies have investigated their impact on brain and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5ed47ef6d4791aac811d47a13335ac
https://doi.org/10.1038/s41386-023-01563-x

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β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement

Autor: Marianne Husson, Léa Tochon, Inés Ibañez-Tallon, Lauriane Harrington, Yoon H. Cho, Uwe Maskos, Vincent David

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, 2020, 40 (17), pp.3465-3477. ⟨10.1523/JNEUROSCI.0356-19.2020⟩
J Neurosci
Journal of Neuroscience, Society for Neuroscience, 2020, 40 (17), pp.3465-3477. ⟨10.1523/JNEUROSCI.0356-19.2020⟩

Nicotine addiction, through smoking, is the principal cause of preventable mortality worldwide. Human genome-wide association studies have linked polymorphisms in theCHRNA5-CHRNA3-CHRNB4gene cluster, coding for the α5, α3, and β4 nicotinic acetylc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2847222a685eaa4da6dfd3bdd9b7f6a
https://doi.org/10.1523/jneurosci.0356-19.2020

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