Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Léa Théroux"'
Autor:
Léa Théroux, Robin Van Den Hauwe, Kien Trân, Justin Fournier, Michael Desgagné, Nathan Meneboo, Alexis Lavallée, Ulrike Fröhlich, Jérôme Côté, Charlie Hollanders, Jean-Michel Longpré, Alexandre Murza, Eric Marsault, Philippe Sarret, Pierre-Luc Boudreault, Steven Ballet
Apelin is an endogenous peptide that is involved in many diseases such as cardiovascular diseases, obesity, and cancer, which has made it an attractive target for drug discovery. Herein, we explore the penultimate and final sequence positions of [Pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bd1073741ed01a6adbbcbf500ae054
https://doi.org/10.1021/acsptsci.2c00219
https://doi.org/10.1021/acsptsci.2c00219
Autor:
Eric Marsault, Robin Van Den Hauwe, Claude Spino, Sabrina Saibi, Xavier Sainsily, Jérôme Côté, Louise Simard, Alexandra Serre, Michel Bouvier, Steven Ballet, Mannix Auger-Messier, Jean-Michel Longpré, Lounès Haroune, Pierre Couvineau, Olivier Lesur, Alexandre Murza, Marco Echevarria, Kien Trân, Léa Théroux, Philippe Sarret
Publikováno v:
Journal of Medicinal Chemistry. 64:5345-5364
Side-chain-constrained amino acids are useful tools to modulate the biological properties of peptides. In this study, we applied side-chain constraints to apelin-13 (Ape13) by substituting the Pro12 and Phe13 positions, affecting the binding affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6326583d9752754accc55d2ff5cb76
https://doi.org/10.1021/acs.jmedchem.0c01941
https://doi.org/10.1021/acs.jmedchem.0c01941
Autor:
Jean-Michel Longpré, Léa Théroux, Philippe Sarret, Michael Desgagné, Marc Sousbie, Lucie Chevillard, Jérôme Côté, Magali Chartier, Charles Rumsby, Lounès Haroune, Eric Marsault, Pierre-Luc Boudreault
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss, Pp 111861-(2021)
Biomedicine and Pharmacotherapy
Biomedicine and Pharmacotherapy, 2021, 141, pp.111861. ⟨10.1016/j.biopha.2021.111861⟩
Biomedicine and Pharmacotherapy
Biomedicine and Pharmacotherapy, 2021, 141, pp.111861. ⟨10.1016/j.biopha.2021.111861⟩
International audience; The current opioid crisis highlights the urgent need to develop safe and effective pain medications. Thus, neurotensin (NT) compounds represent a promising approach, as the antinociceptive effects of NT are mediated by activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab23a033cba3c401f41128a4191afd5
https://pubmed.ncbi.nlm.nih.gov/34229249
https://pubmed.ncbi.nlm.nih.gov/34229249