Výsledky vyhledávání - "Lærke W. Andersen"

The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Autor: Johannes Josef Fels, Henrik Søeborg, Inger Thorup, Mikala Skydsgaard, Lærke W. Andersen, Hanne Offenberg, Kevin A. Keane, Charlotte M. Dalsgaard, Ingrid Sjögren, Jennifer M. Rojas, Line Olrik Berthelsen, Jette Nowak, Florian Bolze, Jes Tovborg Jensen, Majken Dalgaard

Publikováno v: Toxicologic Pathology. 46:777-798

The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720b22f18b55257c12209b4651c6fd5d
https://doi.org/10.1177/0192623318803557

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Kisspeptin-52 partially rescues the activity of the hypothalamus-pituitary-gonadal axis in underweight male rats dosed with an anti-obesity compound

Autor: Emil Egecioglu, Majken Dalgaard, Marie Østergaard Pedersen, Birgitte Schjellerup Wulff, Mikala Skydsgaard, Alan Broadmeadow, Clare J. Chesher, Ridhirama Bhuwania, Esther Bloem, Emma Moore, Manuel Tena-Sempere, Hannah Williams, Lærke W. Andersen, Pia Søndergaard Galle, Florian Bolze, Johan F. Paulsson

Publikováno v: Toxicology and Applied Pharmacology. 404:115152

Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c0139312e6bed6d38c6b05112dbcd
https://doi.org/10.1016/j.taap.2020.115152

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Supplemental Material, DS7_TPX_10.1177_0192623318803557 - The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Autor: Rojas, Jennifer M., Bolze, Florian, Thorup, Inger, Nowak, Jette, Dalsgaard, Charlotte M., Skydsgaard, Mikala, Berthelsen, Line O., Keane, Kevin A., Søeborg, Henrik, Sjögren, Ingrid, Jensen, Jes T., Fels, Johannes J., Offenberg, Hanne K., Lærke W. Andersen, Dalgaard, Majken

Supplemental Material, DS7_TPX_10.1177_0192623318803557 for The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model by Jennifer M. Rojas, Florian Bolze, Inger Thorup, Jette Nowak, Charlotte M. Dalsgaar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a0061e3e1bb0e392fefeaff88d3576

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Supplemental Material, DS3_TPX_10.1177_0192623318803557 - The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Supplemental Material, DS3_TPX_10.1177_0192623318803557 for The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model by Jennifer M. Rojas, Florian Bolze, Inger Thorup, Jette Nowak, Charlotte M. Dalsgaar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063c8b15ef62c770972ba3d01d43274f

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Supplemental Material, DS1_TPX_10.1177_0192623318803557 - The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Supplemental Material, DS1_TPX_10.1177_0192623318803557 for The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model by Jennifer M. Rojas, Florian Bolze, Inger Thorup, Jette Nowak, Charlotte M. Dalsgaar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2198e7e00c27fb7d8e3c935a6fba6640

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Supplemental Material, DS5_TPX_10.1177_0192623318803557 - The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Supplemental Material, DS5_TPX_10.1177_0192623318803557 for The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model by Jennifer M. Rojas, Florian Bolze, Inger Thorup, Jette Nowak, Charlotte M. Dalsgaar

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Supplemental Material, DS8_TPX_10.1177_0192623318803557 - The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

Supplemental Material, DS8_TPX_10.1177_0192623318803557 for The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model by Jennifer M. Rojas, Florian Bolze, Inger Thorup, Jette Nowak, Charlotte M. Dalsgaar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043323fb2a97c8431dd5ff701a4f3f76

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