Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients

Autor: Thomas J. Hjelholt, Anni Winckelmann, Jesper Melchjorsen, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Lærke V. Munk-Petersen, Thomas A Rasmussen, David C. Montefiori

Publikováno v: Winckelmann, A A, Munk-Petersen, L V, Rasmussen, T A, Melchjorsen, J, Hjelholt, T J, Montefiori, D, Ostergaard, L, Søgaard, O S & Tolstrup, M 2013, ' Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients ', P L o S One, vol. 8, no. 4, pp. e62074 . https://doi.org/10.1371/journal.pone.0062074
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e62074 (2013)

Toll-like receptor (TLR) agonists can reactivate HIV from latently infected cells in vitro. We aimed to investigate the TLR-9 agonist, CPG 7909's in vivo effect on the proviral HIV reservoir and HIV-specific immunity. This was a post-hoc analysis of

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