Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53

Autor: Klett T, Schwer M, Ernst LN, Engelhardt MU, Jaag SJ, Masberg B, Knappe C, Lämmerhofer M, Gehringer M, Boeckler FM

Publikováno v: Drug Design, Development and Therapy, Vol Volume 18, Pp 2653-2679 (2024)

Theresa Klett,1,* Martin Schwer,1,* Larissa N Ernst,1,* Marc U Engelhardt,1 Simon J Jaag,2 Benedikt Masberg,2 Cornelius Knappe,2 Michael Lämmerhofer,2 Matthias Gehringer,3,4 Frank M Boeckler1,5 1Laboratory for Molecular Design & Pharmace

Externí odkaz: https://doaj.org/article/1f63e6f5ceef4b5f8aa0a83e869b7c7b

Cross-linked polysiloxane-coated stable bond O-9-(2,6-diisopropylphenylcarbamoyl)quinine and quinidine chiral stationary phases as well as application in enantioselective cryo-HPLC.

Autor: Woiwode U; Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Tübingen, Germany., Sievers-Engler A; Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Tübingen, Germany., Lämmerhofer M; Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Tübingen, Germany.

Publikováno v: Electrophoresis [Electrophoresis] 2024 Jun; Vol. 45 (11-12), pp. 989-999. Date of Electronic Publication: 2023 Nov 02.

Author Correction: Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus.

Autor: Torres Salazar BO; Department of Infection Biology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany., Dema T; Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany., Schilling NA; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany., Janek D; Department of Infection Biology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany., Bornikoel J; Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany., Berscheid A; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany.; Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany., Elsherbini AMA; Department of Infection Biology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany., Krauss S; Department of Infection Biology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany., Jaag SJ; Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany., Lämmerhofer M; Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany., Li M; Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China., Alqahtani N; Department of Infection Biology and Microbiomes, University of Liverpool, Liverpool, UK., Horsburgh MJ; Department of Infection Biology and Microbiomes, University of Liverpool, Liverpool, UK., Weber T; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Beltrán-Beleña JM; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany., Brötz-Oesterhelt H; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany.; Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany., Grond S; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany. stephanie.grond@uni-tuebingen.de.; Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany. stephanie.grond@uni-tuebingen.de., Krismer B; Department of Infection Biology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany. b.krismer@uni-tuebingen.de.; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany. b.krismer@uni-tuebingen.de.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany. b.krismer@uni-tuebingen.de., Peschel A; Department of Infection Biology, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.; Cluster of Excellence EXC 2124 Controlling Microbes to Fight Infections, Tübingen, Germany.; German Center for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Dec; Vol. 9 (12), pp. 3393.

Hemin promotes platelet activation and plasma membrane disintegration regulated by the subtilisin-like proprotein convertase furin.

Autor: Schaale D; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Laspa Z; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Balmes A; Institute of Applied Physics, Eberhard Karls University of Tübingen, Tübingen, Germany., Sigle M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Dicenta-Baunach V; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Hochuli R; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Fu X; Institute of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Eberhard Karls University of Tübingen, Tübingen, Germany., Serafimov K; Institute of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Eberhard Karls University of Tübingen, Tübingen, Germany., Castor T; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Harm T; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Müller KAL; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Rohlfing AK; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany., Laufer S; Institute of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Eberhard Karls University of Tübingen, Tübingen, Germany., Schäffer TE; Institute of Applied Physics, Eberhard Karls University of Tübingen, Tübingen, Germany., Lämmerhofer M; Institute of Pharmaceutical Sciences, Department of Pharmaceutical and Medicinal Chemistry, Eberhard Karls University of Tübingen, Tübingen, Germany., Gawaz M; Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University of Tübingen, Tübingen, Germany.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Nov 15; Vol. 38 (21), pp. e70155.

Non-enantioselective, enantioselective, and two-dimensional liquid chromatography coupled with tandem mass spectrometry for the study of stereochemical disposition of oxylipins in cGMP-regulated hemin-treated platelets.

Autor: Fu X; University of Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, Auf der Morgenstelle 8, Tübingen 72076, Germany. Electronic address: xiaoqing.fu@uni-tuebingen.de., Knappe C; University of Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, Auf der Morgenstelle 8, Tübingen 72076, Germany., Rohlfing AK; Department of Cardiology and Angiology, University Hospital Tübingen, Otfried-Müller-Strasse 10, Tübingen 72076, Germany., Gawaz MP; Department of Cardiology and Angiology, University Hospital Tübingen, Otfried-Müller-Strasse 10, Tübingen 72076, Germany., Lämmerhofer M; University of Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, Auf der Morgenstelle 8, Tübingen 72076, Germany. Electronic address: michael.laemmerhofer@uni-tuebingen.de.

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Sep 15; Vol. 248, pp. 116328. Date of Electronic Publication: 2024 Jun 26.