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pro vyhledávání: '"Lázaro Navarro, Juan"'
Autor:
Lázaro Navarro, Juan
Die jüngsten Fortschritte in der Behandlung haben das Gesamtüberleben von Kindern mit akuter lymphoblastischer Leukämie (ALL) verbessert. Dennoch erleiden 20 % der Kinder mit ALL Rückfälle, was die Notwendigkeit neuer zielgerichteter Behandlungs
Externí odkaz:
http://edoc.hu-berlin.de/18452/29708
Akademický článek
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Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 17. Uncropped electrophoretic gel of Fig. 3. A RT-PCR was used to confirm overexpression of pCYB5Aalt in NALM-6 cell line. Uncropped electrophoretic gel (agarose, 1.6%) of RT-PCR results of Fig. 3 are shown. Cells were transfected wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a490fc7291782d2fcb4f191e433a3e
Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 3. RNAseq pipeline algorithms of cohort 1 and cohort 2. RNAseq workflow is shown for cohort 1 and cohort 2 including most important steps of patient material collection, processing and data analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab89c6d95c36ec48e71c17668402970
Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 9. CYB5Aalt mRNA expression across molecular subtypes in cohort 3. CYB5Aalt expression (TPM log2) is shown across molecular subgroups in cohort 3. Only samples with detectable CYB5Aalt expression (n = 22) are displayed. Subgroups with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44df5f3942c09f42177bb95b5619f34
Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 7. Validation of CYB5Aalt in patient samples via RT-PCR and Sanger Sequencing. A RT-PCR with specific primers reaching from alternative Exon 1 to Exon 2 of CYB5A WT confirms expression of CYB5Aalt in cDNA derived from two representati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58299985197d8a662652d18a670c24e9
Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 6. Schematic illustration of CYB5A WT- and CYB5Aalt-transcript. The graphic summarises the differences between CYB5A WT (top) and CYB5Aalt (bottom) at a transcript level. The WT ORF (dark grey), starts in exon 1, marked by “ATG” a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a9b59e3b3bbd2f25bf9f09996c737c
Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 8. Heatmap of subgroup-specific RNA expression profiles shows subgroup specificity of CYB5Aalt in cohort 2. Unsupervised clustering (Euclidean, Average Linkage) of 500 most variably expressed genes was performed in cohort 2 (n = 140).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca0c62d18f00b54ff3312fc62a82afa
Autor:
Bartsch, Lorenz, Schroeder, Michael P., Hänzelmann, Sonja, Bastian, Lorenz, Lázaro-Navarro, Juan, Schlee, Cornelia, Tanchez, Jutta Ortiz, Schulze, Veronika, Isaakidis, Konstandina, Rieger, Michael A., Gökbuget, Nicola, Eckert, Cornelia, Serve, Hubert, Horstmann, Martin, Schrappe, Martin, Brüggemann, Monika, Baldus, Claudia D., Neumann, Martin
Additional file 4. Heatmap of subgroup-specific RNA expression profiles shows subgroup specificity of CYB5Aalt in cohort 1. Unsupervised clustering (Euclidean, Average Linkage) of 500 most variably expressed genes is shown in samples of cohort 1 (n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544e31b3f942583374c05ed2c77366d7
Autor:
Lázaro-Navarro, Juan, Pimentel-Gutiérrez, Helia Judith, Gauert, Anton, Hagemann, Anja I.H., Eisenschmid, Jassi, Gökbuget, Nicola, Vick, Binje, Jeremias, Irmela, Seyfried, Felix, Meyer, Lüder Hinrich, Debatin, Klaus-Michael, Richer, Kathrin, Bultman, Miriam, Neumann, Martin, Hänzelmann, Sonja, Serve, Hubert, Astrahantseff, Kathy, Rieger, Michael A., Eckert, Cornelia, Baldus, Claudia D., Bastian, Lorenz *
Publikováno v:
In Blood Advances 28 December 2021 5(24):5501-5506