Zobrazeno 1 - 10
of 28
pro vyhledávání: '"László Tora"'
Autor:
Gizem Yayli, Andrea Bernardini, Paulina Karen Mendoza Sanchez, Elisabeth Scheer, Mylène Damilot, Karim Essabri, Bastien Morlet, Luc Negroni, Stéphane D. Vincent, H.T. Marc Timmers, László Tora
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113099- (2023)
Summary: To understand the function of multisubunit complexes, it is of key importance to uncover the precise mechanisms that guide their assembly. Nascent proteins can find and bind their interaction partners during their translation, leading to co-
Externí odkaz:
https://doaj.org/article/7c3160e0e5134daeb9335018d23b6679
Autor:
Marjorie Fournier, Amélie Rodrigue, Larissa Milano, Jean-Yves Bleuyard, Anthony M Couturier, Jacob Wall, Jessica Ellins, Svenja Hester, Stephen J Smerdon, László Tora, Jean-Yves Masson, Fumiko Esashi
Publikováno v:
eLife, Vol 11 (2022)
The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that the lysine acetyltransfe
Externí odkaz:
https://doaj.org/article/5d62dc5a4b634c96b8938dd0c1b86dd9
Autor:
Changwei Yu, Nevena Cvetesic, Vincent Hisler, Kapil Gupta, Tao Ye, Emese Gazdag, Luc Negroni, Petra Hajkova, Imre Berger, Boris Lenhard, Ferenc Müller, Stéphane D. Vincent, László Tora
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The vertebrate TATA-binding protein (TBP) paralogue (TBPL2) is only expressed in growing oocytes, where TBP is absent. Here the authors highlight a unique role for the TBPL2/TFIIA complex in the establishment of the oocyte transcriptome by using a sp
Externí odkaz:
https://doaj.org/article/17a2545846504f2fb6572d460793c1a3
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7459 (2022)
Ubiquitin (ub) is a small, highly conserved protein widely expressed in eukaryotic cells. Ubiquitination is a post-translational modification catalyzed by enzymes that activate, conjugate, and ligate ub to proteins. Substrates can be modified either
Externí odkaz:
https://doaj.org/article/4227298c773c47a6bc1b115d63772d10
Autor:
Ivanka Kamenova, Pooja Mukherjee, Sascha Conic, Florian Mueller, Farrah El-Saafin, Paul Bardot, Jean-Marie Garnier, Doulaye Dembele, Simona Capponi, H. T. Marc Timmers, Stéphane D. Vincent, László Tora
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Genes encoding protein complex subunits are often dispersed in the genome of eukaryotes, raising the question how these protein complexes assemble. Here, the authors provide evidence that mammalian nuclear transcription complexes are formed co-transl
Externí odkaz:
https://doaj.org/article/bbc82790458b46f6b41118387d376ef9
Autor:
Marjorie Fournier, Meritxell Orpinell, Cédric Grauffel, Elisabeth Scheer, Jean-Marie Garnier, Tao Ye, Virginie Chavant, Mathilde Joint, Fumiko Esashi, Annick Dejaegere, Pierre Gönczy, László Tora
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The acetyltransferases KAT2A and KAT2B are essential regulators of transcription, cell cycle progression and DNA repair. Here the authors describe a KAT2A/2B-dependent acetylome, and show that acetylation of the protein kinase PLK4 contributes to the
Externí odkaz:
https://doaj.org/article/250c67199f71459cb19a3733c6507eda
Publikováno v:
Bio-Protocol, Vol 8, Iss 21 (2018)
The spatiotemporal localization of different intracellular factors in real-time and their detection in live cells are important parameters to understand dynamic protein-based processes. Therefore, there is a demand to perform live-cell imaging and to
Externí odkaz:
https://doaj.org/article/292f5b1ebd194922b1aa0eccb1c08e32
Autor:
Marjorie Fournier, László Tora
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 2 (2017)
We have recently identified the first human lysine (K) acetyltransferase 2A and 2B (called KAT2A/2B; known also as GCN5/PCAF, respectively)-dependent acetylome and revealed a mechanism by which KAT2A/2B-mediated acetylation of serine/threonine polo-l
Externí odkaz:
https://doaj.org/article/ec6964e0158c4803b495f44a677e95b3
Autor:
Andrea Bernardini, Pooja Mukherjee, Elisabeth Scheer, Ivanka Kamenova, Simona Antonova, Paulina Karen Mendoza Sanchez, Gizem Yayli, Bastien Morlet, H.T. Marc Timmers, László Tora
Large heteromeric multiprotein complexes play pivotal roles at every step of gene expression in eukaryotic cells. Among them, the 20-subunit basal transcription factor TFIID nucleates RNA polymerase II preinitiation complex at gene promoters. Here, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d5df563b51359bf063c0243cbddbae1
https://doi.org/10.1101/2023.04.05.535704
https://doi.org/10.1101/2023.04.05.535704
Autor:
Veronique Fischer, Vincent Hisler, Elisabeth Scheer, Elisabeth Lata, Bastien Morlet, Damien Plassard, Dominique Helmlinger, Didier Devys, László Tora, Stéphane D Vincent
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2022, pp.gkac637. ⟨10.1093/nar/gkac637⟩
Nucleic Acids Research, 2022, pp.gkac637. ⟨10.1093/nar/gkac637⟩
Coactivator complexes regulate chromatin accessibility and transcription. SAGA (Spt-Ada-Gcn5 Acetyltransferase) is an evolutionary conserved coactivator complex. The core module scaffolds the entire SAGA complex and adopts a histone octamer-like stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da54334657579507e80dafa9f99c9ed2
https://www.hal.inserm.fr/inserm-03741582/document
https://www.hal.inserm.fr/inserm-03741582/document