Zobrazeno 1 - 10
of 208
pro vyhledávání: '"László Somsák"'
Autor:
István Kacsir, Adrienn Sipos, Tímea Kiss, Evelin Major, Nikolett Bajusz, Emese Tóth, Péter Buglyó, László Somsák, Gábor Kardos, Péter Bai, Éva Bokor
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
The toxicity of and resistance to platinum complexes as cisplatin, oxaliplatin or carboplatin calls for the replacement of these therapeutic agents in clinical settings. We have previously identified a set of half sandwich-type osmium, ruthenium and
Externí odkaz:
https://doaj.org/article/a097cc70cbab47e5ba06c9f405874d2d
Publikováno v:
Molecules, Vol 28, Iss 7, p 3005 (2023)
Glycogen phosphorylase (GP) is a key regulator of glucose levels and, with that, an important target for the discovery of novel treatments against type 2 diabetes. β-d-Glucopyranosyl derivatives have provided some of the most potent GP inhibitors di
Externí odkaz:
https://doaj.org/article/a70acb83a9f24ff8a4f335f8cfec9783
Autor:
István Kacsir, Adrienn Sipos, Evelin Major, Nikolett Bajusz, Attila Bényei, Péter Buglyó, László Somsák, Gábor Kardos, Péter Bai, Éva Bokor
Publikováno v:
Molecules, Vol 28, Iss 7, p 3058 (2023)
While platinum-based compounds such as cisplatin form the backbone of chemotherapy, the use of these compounds is limited by resistance and toxicity, driving the development of novel complexes with cytostatic properties. In this study, we synthesized
Externí odkaz:
https://doaj.org/article/30af28179b93455b82bd4840db51a689
Autor:
Bence Balázs, Zoltán Tóth, István Kacsir, Adrienn Sipos, Péter Buglyó, László Somsák, Éva Bokor, Gábor Kardos, Péter Bai
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Bacterial resistance to antibiotics is an ever-growing problem in heathcare. We have previously identified a set of osmium(II), ruthenium(II), iridium(III) and rhodium(III) half-sandwich type complexes with bidentate monosaccharide ligands possessing
Externí odkaz:
https://doaj.org/article/a2acd9585db44ca6a45330e393caa0c9
Autor:
Anastasia S. Tsagkarakou, Styliani A. Chasapi, Symeon M. Koulas, Ioannis Tsialtas, Efthimios Kyriakis, Christina E. Drakou, Sándor Kun, László Somsák, Georgios A. Spyroulias, Anna-Maria G. Psarra, Demetres D. Leonidas
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 3, Iss , Pp 100011- (2021)
The binding of p-coumaroyl glucose to glycogen phosphorylase (GP; a pharmaceutical target for the development of antihyperglycaemic drugs) has been studied by kinetics, and X-ray crystallography while its effect to HepG2 cells metabolism has been ass
Externí odkaz:
https://doaj.org/article/a49cf742850049f58c1a058409ebcdff
Publikováno v:
Molecules, Vol 27, Iss 22, p 7785 (2022)
Glycosylidene-spiro-morpholin(on)es are scarcely described skeletons in the literature. In this work, we have systematically explored the synthetic routes towards such morpholinones based on the reactions of O-peracylated hept-2-ulopyranosonamide der
Externí odkaz:
https://doaj.org/article/e4534db4b10c42039f8448224182f480
Autor:
Éva Bokor, Attila Ferenczi, Mahir Hashimov, Éva Juhász-Tóth, Zsófia Götz, Alshimaa Ibrahim Zaki, László Somsák
Publikováno v:
Molecules, Vol 27, Iss 22, p 7801 (2022)
C-glycopyranosyl derivatives of six-membered heterocycles are scarcely represented in the chemical literature and the title 3-glycopyranosyl-1,2,4-triazines are completely unknown. In this paper, the first synthesis of this compound class is accompli
Externí odkaz:
https://doaj.org/article/b01cddca7157495cb2be14b7d0881ebc
Autor:
Tímea Kaszás, Balázs Áron Baráth, Bernadett Balázs, Tekla Blága, László Juhász, László Somsák, Marietta Tóth
Publikováno v:
Molecules, Vol 27, Iss 6, p 1795 (2022)
A catalyst-free coupling reaction between O-peracetylated, O-perbenzoylated, O-permethylated, and O-permethoxymethylated 2,6-anhydro-aldose tosylhydrazones (C-(β-d-glycopyranosyl)formaldehyde tosylhydrazones) and aromatic boronic acids is reported.
Externí odkaz:
https://doaj.org/article/666b4a1d7d4a409fafdf193496a276c9
Autor:
Lilla Nagy, Ferenc Béke, László Juhász, Tünde Kovács, Éva Juhász-Tóth, Tibor Docsa, Attila Tóth, Pál Gergely, László Somsák, Péter Bai
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0236081 (2020)
Type 2 diabetes mellitus (T2DM), one of the most common metabolic diseases, is characterized by insulin resistance and inadequate insulin secretion of β cells. Glycogen phosphorylase (GP) is the key enzyme in glycogen breakdown, and contributes to h
Externí odkaz:
https://doaj.org/article/ccd98b64c7e4413ca14929aa806fc085
Autor:
Ádám Sipos, Eszter Szennyes, Nikolett Éva Hajnal, Sándor Kun, Katalin E. Szabó, Karen Uray, László Somsák, Tibor Docsa, Éva Bokor
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 364 (2021)
A current trend in the quest for new therapies for complex, multifactorial diseases, such as diabetes mellitus (DM), is to find dual or even multi-target inhibitors. In DM, the sodium dependent glucose cotransporter 2 (SGLT2) in the kidneys and the g
Externí odkaz:
https://doaj.org/article/123aa2e339ec4bb68099bd3b1990d15b