Zobrazeno 1 - 10
of 78
pro vyhledávání: '"László G Kömüves"'
Autor:
Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi
Publikováno v:
eLife, Vol 8 (2019)
Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hem
Externí odkaz:
https://doaj.org/article/447fe82d1b704055b7ba75eb3ece6428
Autor:
Donghong Yan, Keira Garland, Marie-Gabrielle Braun, Yiming Xu, Anand Kumar Katakam, Emily J. Hanan, Yutian Peng, Jing Kang, Meredith Sagolla, Jingyu Diao, Homer Pantua, Cary D. Austin, Cameron L. Noland, Sharookh B. Kapadia, Georgette Castanedo, Zora Modrusan, Min Xu, Susan L. Gloor, Janina Reeder, Elizabeth Skippington, László G. Kömüves, Jeremy Murray
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
mBio
mBio
Despite increasing evidence suggesting that antibiotic heteroresistance can lead to treatment failure, the significance of this phenomena in the clinic is not well understood, because many clinical antibiotic susceptibility testing approaches lack th
Autor:
Matthew L. Albert, Zia Khan, Margaret Solon, Trinna L. Cuellar, Timothy W. Behrens, Anna-Maria Herzner, Benjamin Haley, László G. Kömüves, Eric L. Van Nostrand, Gene W. Yeo, Ronald Chen, Zora Modrusan, Sara Chan, Ximo Pechuan-Jorge
Publikováno v:
The Journal of Experimental Medicine
hnRNPC prevents release of inverted-repeat Alu double-stranded RNA into the cytosol by masking cryptic splice sites. Herzner et al. found that deficiency in hnRNPC led to dysregulation of splicing and increased abundance of intronic double-stranded R
Autor:
Emily B. Gogol, Christopher M. Koth, Weiru Wang, Robert Piskol, Yue Fu, Simon Hansen, Aaron H. Nile, Lijuan Zhou, Wayne J. Fairbrother, Felipe De Sousa E Melo, Susmith Mukund, Yvonne Franke, László G. Kömüves, Yingnan Zhang, Rami N. Hannoush, Zora Modrusan, Stephane Angers, Frederic J. de Sauvage
Publikováno v:
Nature Chemical Biology. 14:582-590
Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the crypt, that express leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5). The Frizzled (FZD) 7 receptor (F
Autor:
Alvin Gogineni, David A. Lawrence, Hai Ngu, Jeffrey Settleman, Avi Ashkenazi, Heather A. Flores, Pradeep M. Nair, Robert F. Kelley, Scot A. Marsters, László G. Kömüves, Meredith Sagolla, Richard Bourgon
Publikováno v:
Proceedings of the National Academy of Sciences. 112:5679-5684
TNF superfamily death ligands are expressed on the surface of immune cells and can trigger apoptosis in susceptible cancer cells by engaging cognate death receptors. A recombinant soluble protein comprising the ectodomain of Apo2 ligand/TNF-related a
Autor:
Jeffrey Eastham-Anderson, Menno van Lookeren Campagne, Peter Gribling, Lauri Diehl, Anusha Ponakala, Jeannie Q. He, Kenneth J. Katschke, Eric Suto, Jackson G. Egen, Wyne P. Lee, László G. Kömüves
Publikováno v:
Journal of Leukocyte Biology. 93:301-306
CRIg plays a critical role in regulating Kupffer cell function and survival in response to adenovirus infection. Whereas adenoviral vectors are known to activate the complement cascade, leading to fixation of C3 proteins to the viral capsid, the cons
Autor:
Lauri Diehl, Gabriele Schaefer, Sharookh B. Kapadia, Jingyu Diao, László G. Kömüves, Homer Pantua, Hai Ngu
Publikováno v:
Journal of Virology. 86:10935-10949
While epidermal growth factor receptor (EGFR) has been shown to be important in the entry process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by which EGFR facilitates HCV entry are not well understood. Using the
Autor:
Shahram Misaghi, Salina Louie, Mohamed Lamkanfi, Jinfeng Liu, Laurie L. Gilmour, Nobuhiko Kayagaki, Anita Izrael-Tomasevic, Yan Qu, Denise M. Monack, James E. Cupp, David Arnott, Kim Newton, Vishva M. Dixit, László G. Kömüves
Publikováno v:
Nature. 490:539-542
Phosphorylation of the NOD-like receptor NLRC4 is essential for activation of the NLRC4 inflammasome complex in response to bacterial stimuli. The NOD-like receptor NLRC4 acts as an inflammasome receptor and is an important part of the innate immune
Autor:
Hai Ngu, Marcin Kowanetz, Xiumin Wu, László G. Kömüves, Alicia S. Chung, Franklin Peale, Guanglei Zhuang, David Finkle, Napoleone Ferrara
Publikováno v:
The Journal of Pathology. 227:404-416
Inhibiting angiogenesis has become an important therapeutic strategy for cancer treatment but, like other current targeted therapies, benefits experienced for late-stage cancers can be curtailed by inherent refractoriness or by acquired drug resistan
Autor:
Philip E. Hass, Cecile Chalouni, Peter Liu, Ben Chih, Wendy Sandoval, Yvonne Chinn, László G. Kömüves, Andrew S. Peterson
Publikováno v:
Nature Cell Biology. 14:61-72
Using RNAi screening, proteomics, cell biological and mouse genetics approaches, we have identified a complex of nine proteins, seven of which are disrupted in human ciliopathies. A transmembrane component, TMEM231, localizes to the basal body before