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pro vyhledávání: '"László Ürögdi"'
Autor:
János Gerencsér, Zoltán Novák, Piroska Gyárfás, László Ürögdi, S. Todd Meyer, Wade Warren Stanfield
Publikováno v:
Synlett. 30:2273-2278
An efficient method for nucleophilic aromatic substitution on 7-azaindoles has been developed. The reaction is facilitated by the unique dual influence of SEM as both protecting and activating group, permitting mild conditions and short reaction time
Autor:
László Ürögdi, Alex Rohde, Jennifer Lynn Gage, Sasha Gragerov, György Dormán, Rene Onrust, Vince Florio, Neil S. Cutshall, Derek Johnston, Andrew Osnowski, Harbol Kevin L, Thomas Neil Wheeler, Lee Mitchell, Wendy MacDonald
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4155-4159
Cyclic nucleotide phosphodiesterases (PDEs) are represented by a large superfamily of enzymes. A series of hydrazone-based inhibitors was synthesized and shown to be novel, potent, and selective against PDE10A. Optimized compounds of this class were