Výsledky vyhledávání - "LÆRKE S. GASBJERG"

Akademický článek

Protocol for assessing the effects of exogenous hormone administration on human postprandial glucose metabolism, appetite sensations, and food intake

Autor: Christoffer A. Hagemann, Lærke S. Gasbjerg, Mikkel B. Christensen, Filip K. Knop

Publikováno v: STAR Protocols, Vol 4, Iss 1, Pp 102070- (2023)

Summary: Here, we present a protocol for a randomized, double-blind, placebo-controlled, crossover trial to evaluate the effects of a continuous intravenous infusion of a native liver-derived hormone, liver-expressed antimicrobial peptide 2 (LEAP2),

Externí odkaz: https://doaj.org/article/daadf20f085246c4b8e33ca448054aa9

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Akademický článek

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

Publikováno v: Cell Reports, Vol 21, Iss 6, Pp 1452-1460 (2017)

Summary: Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution

Externí odkaz: https://doaj.org/article/b5aa1694774f4b23bb8fed0e16aceb6a

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Rare heterozygous loss-of-function variants in the human GLP-1 receptor do not associate with cardiometabolic phenotypes

Autor: Josefine U Melchiorsen, Kimmie V Sørensen, Jette Bork-Jensen, Hüsün S Kizilkaya, Lærke S Gasbjerg, Alexander S Hauser, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Anette P Gjesing, Jens J Holst, Torben Hansen, Mette M Rosenkilde, Niels Grarup

Publikováno v: The Journal of Clinical Endocrinology & Metabolism.

Context Impact of lost GLP-1 receptor function in human physiology. Objective Identify coding nonsynonymous GLP1R variants in Danish individuals to link their in vitro phenotypes and clinical phenotypic associations. Methods We sequenced GLP1R in 8,6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f42765a2459edd5eb09d9dd7deb86cd2
https://doi.org/10.1210/clinem/dgad290

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Acute concomitant glucose‐dependent insulinotropic polypeptide receptor antagonism during glucagon‐like peptide 1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity

Autor: Signe Stensen, Liva L. Krogh, Alexander H. Sparre‐Ulrich, Flemming Dela, Bolette Hartmann, Tina Vilsbøll, Jens J. Holst, Mette M. Rosenkilde, Mikkel B. Christensen, Lærke S. Gasbjerg, Filip K. Knop

Publikováno v: Diabetes, Obesity and Metabolism. 24:1882-1887

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72117d1cb63dd140d1255e1806c2ded2
https://doi.org/10.1111/dom.14736

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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans

Autor: Liva S L Krogh, Kristine Henriksen, Signe Stensen, Kirsa Skov-Jeppesen, Natasha C Bergmann, Joachim Størling, Mette M Rosenkilde, Bolette Hartmann, Jens J Holst, Lærke S Gasbjerg, Filip K Knop

Publikováno v: European Journal of Endocrinology. 188

ObjectiveThe gut hormone glucose-dependent insulinotropic polypeptide (GIP) is an important regulator of glucose and bone metabolism. In rodents, the naturally occurring GIP variant, GIP(1-30)NH2, has shown similar effects as full-length GIP (GIP(1-4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a404840649d866f6f9723e84652db3bc
https://doi.org/10.1093/ejendo/lvac015

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The importance of endogenously secreted GLP-1 and GIP for postprandial glucose tolerance and β-cell function after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

Autor: Morten Hindsø, Nora Hedbäck, Maria S. Svane, Andreas Møller, Christoffer Martinussen, Nils B. Jørgensen, Carsten Dirksen, Lærke S. Gasbjerg, Viggo B. Kristiansen, Bolette Hartmann, Mette M. Rosenkilde, Jens J. Holst, Sten Madsbad, Kirstine N. Bojsen-Møller

Enhanced secretion of glucagon-like peptide-1 (GLP-1) seems to be essential for improved postprandial β-cell function after Roux-en-Y gastric bypass (RYGB) but is less studied after sleeve gastrectomy (SG). Moreover, the role of the other major incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b77637617818928918ec277a545b2d8
https://doi.org/10.2337/figshare.21675275.v1

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The Gut-Bone Axis in Diabetes

Autor: Henrik, Maagensen, Mads M, Helsted, Lærke S, Gasbjerg, Tina, Vilsbøll, Filip K, Knop

Publikováno v: Current osteoporosis reportsPapers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance.

To describe recent advances in the understanding of how gut-derived hormones regulate bone homeostasis in humans with emphasis on pathophysiological and therapeutic perspectives in diabetes.The gut-derived incretin hormone glucose-dependent insulinot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d843543491c7a4621d70e87a0d4d4a6
https://pubmed.ncbi.nlm.nih.gov/36441432

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Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults

Publikováno v: Demant, M, Suppli, M P, Foghsgaard, S, Gether, L, Grøndahl, M F G, Dalsgaard, N B, Bergmann, S S, Lanng, A R, Gasbjerg, L S, Thomasen, M, Bagger, J I, Strandberg, C, Kønig, M J, Grønbæk, H, Becker, U, Wewer Albrechtsen, N J, Holst, J J, Knop, J, Gillum, M P, Vilsbøll, T & Knop, F K 2021, ' Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults ', European Journal of Endocrinology, vol. 185, no. 1, pp. 23-32 . https://doi.org/10.1530/EJE-21-0122
Demant, M, Suppli, M P, Foghsgaard, S, Gether, L, Grøndahl, M F G, Dalsgaard, N B, Bergmann, S S, Lanng, A R, Gasbjerg, L S, Thomasen, M, Bagger, J I, Strandberg, C, Kønig, M J, Grønbæk, H, Becker, U, Holst, J J, Knop, J, Gillum, M P, Vilsbøll, T & Knop, F K 2021, ' Metabolic effects of 1-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults ', European Journal of Endocrinology, vol. 185, no. 1, pp. 23-32 . https://doi.org/10.1530/EJE-21-0122

Aims/hypothesis Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (1 week of binge drinking and junk food consumptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6360ee13ff03cdf01cb4fca67796d4
https://doi.org/10.1530/eje-21-0122

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Effects of endogenous GIP in patients with type 2 diabetes

Autor: Bolette Hartmann, Liva S.L. Krogh, Filip K. Knop, Mette M. Rosenkilde, Alexander Hovard Sparre-Ulrich, Tina Vilsbøll, Kirsa Skov-Jeppesen, Jens J. Holst, Mette H. Jensen, Mikkel B. Christensen, Flemming Dela, Lærke S. Gasbjerg, Signe Stensen

Publikováno v: Stensen, S, Gasbjerg, L S, Krogh, L L, Skov-Jeppesen, K, Sparre-Ulrich, A H, Jensen, M H, Dela, F, Hartmann, B, Vilsbøll, T, Holst, J J, Rosenkilde, M M, Christensen, M B & Knop, F K 2021, ' Effects of endogenous GIP in patients with type 2 diabetes ', European Journal of Endocrinology, vol. 185, no. 1, pp. 33-45 . https://doi.org/10.1530/EJE-21-0135

Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf5ca0367b3c3458d200af3686a07ef
https://doi.org/10.1530/eje-21-0135

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