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Pharmacokinetics and anti-hyperglycaemic efficacy of a novel inhibitor of glycogen phosphorylase, 1,4-dideoxy-1,4-imino-d- arabinitol, in glucagon-challenged rats and dogs and in diabetic ob/ob mice

Autor: L. Ynddal, J. V. Andersen, J. G. McCormack, P. Mackay

Publikováno v: Diabetes, Obesity and Metabolism. 5:397-407

Aim: To further characterize the properties of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB), a recently described novel and potent inhibitor of glycogen phosphorylase and potential anti-diabetic agent, we have determined its pharmacokinetic properties in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcc6c3e5a32ba6f7788e7011d6ac7d53
https://doi.org/10.1046/j.1463-1326.2003.00293.x

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The pharmacokinetics, pharmacodynamics, safety and tolerability following 7 days daily oral treatment with NN703 in healthy male subjects

Autor: J.F. Falch, Mikael S. Thomsen, L. Ynddal, H. Agersoe, L. Eliot, B. Søgaard, Mapoko M. Ilondo, Tina Christiansen, Milan Zdravkovic

Publikováno v: Growth Hormone & IGF Research. 11:41-48

The aim of the present study was to assess the safety, pharmacokinetics and pharmacodynamics (including specificity) of NN703 (tabimorelin), a growth hormone (GH) secretagogue, in healthy male subjects following treatment for 7 days once-daily. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67fd4231d931052a9fe174a11a196c5
https://doi.org/10.1054/ghir.2000.0188

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The pharmacokinetics, pharmacodynamics, safety and tolerability of a single dose of NN703, a novel orally active growth hormone secretagogue in healthy male volunteers

Autor: B. Søgaard, J.E. Falch, L. Ynddal, Henrik Agersø, Mapoko M. Ilondo, Milan Zdravkovic, Thomas Christiansen, Mikael S. Thomsen

Publikováno v: Growth Hormone & IGF Research. 10:193-198

The aim of the present study was to investigate the pharmacodynamics, pharmacokinetics, safety and tolerability of a single dose of NN703 (tabimorelin), a growth hormone secretagogue in healthy male subjects. The study design was double blind, random

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462cd36e26696eb18924d9ea5e92f887
https://doi.org/10.1054/ghir.2000.0152

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Pharmacokinetics and anti-hyperglycaemic efficacy of a novel inhibitor of glycogen phosphorylase, 1,4-dideoxy-1,4-imino-d- arabinitol, in glucagon-challenged rats and dogs and in diabetic ob/ob mice

Autor: P, Mackay, L, Ynddal, J V, Andersen, J G, McCormack

Publikováno v: Diabetes, obesitymetabolism. 5(6)

To further characterize the properties of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB), a recently described novel and potent inhibitor of glycogen phosphorylase and potential anti-diabetic agent, we have determined its pharmacokinetic properties in rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a73a8f8b56049566fec1f01ced210e9
https://pubmed.ncbi.nlm.nih.gov/14617225

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Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers

Autor: J V, Gobburu, H, Agersø, W J, Jusko, L, Ynddal

Publikováno v: Pharmaceutical research. 16(9)

To examine the pharmacokinetics (PK) and pharmacodynamics (PD) of ipamorelin, a growth hormone (GH) releasing peptide, in healthy volunteers.A trial was conducted with a dose escalation design comprising 5 different infusion rates (4.21, 14.02, 42.13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::de6f7cabfad97eb7a0984f58f3a30281
https://pubmed.ncbi.nlm.nih.gov/10496658

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Akademický článek

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Akademický článek

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