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Akademický článek

Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection

Autor: Alanna G. Spiteri, Claire L. Wishart, Duan Ni, Barney Viengkhou, Laurence Macia, Markus J. Hofer, Nicholas J. C. King

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-27 (2023)

Abstract As the resident parenchymal myeloid population in the central nervous system (CNS), microglia are strategically positioned to respond to neurotropic virus invasion and have been implicated in promoting both disease resolution and progression

Externí odkaz: https://doaj.org/article/7a43bb50ad4e4929b9aa65ff14a72977

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Akademický článek

High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease

Autor: Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King

Publikováno v: Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)

Abstract Background Differentiating infiltrating myeloid cells from resident microglia in neuroinflammatory disease is challenging, because bone marrow-derived inflammatory monocytes infiltrating the inflamed brain adopt a ‘microglia-like’ phenot

Externí odkaz: https://doaj.org/article/ebf58f4e1d3f4998b8f08e4ddf92213b

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Akademický článek

Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis

Autor: Tayler F. L. Wishart, Frank J. Lovicu

Publikováno v: Cells, Vol 12, Iss 10, p 1364 (2023)

Heparan sulphate proteoglycans (HSPGs) consist of a core protein decorated with sulphated HS-glycosaminoglycan (GAG) chains. These negatively charged HS-GAG chains rely on the activity of PAPSS synthesising enzymes for their sulfation, which allows t

Externí odkaz: https://doaj.org/article/6ebe715451af4daf96645ab557fde24a

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Akademický článek

Immovable Object Meets Unstoppable Force? Dialogue Between Resident and Peripheral Myeloid Cells in the Inflamed Brain

Autor: Alanna G. Spiteri, Claire L. Wishart, Nicholas J. C. King

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Inflammation of the brain parenchyma is characteristic of neurodegenerative, autoimmune, and neuroinflammatory diseases. During this process, microglia, which populate the embryonic brain and become a permanent sentinel myeloid population, are inexor

Externí odkaz: https://doaj.org/article/df4f89a719764b5084e4893742bd6db5

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Akademický článek

Gymnastic-Based Movement Therapy for Children With Neurodevelopmental Disabilities: Results From a Pilot Feasibility Study

Autor: Mojgan Gitimoghaddam, William H. McKellin, Anton R. Miller, Jonathan A. Weiss, Annette Majnemer, Louise C. Mâsse, Rollin Brant, Vivien Symington, Robert L. Wishart, Jean-Paul Collet

Publikováno v: Frontiers in Pediatrics, Vol 7 (2019)

Background: Developmental and behavioral issues often limit the participation of children with neurodevelopmental disabilities (NDD) in community-based activities with their peers, which decreases opportunities for their social learning and developme

Externí odkaz: https://doaj.org/article/d089e572ae0c4b009c18e207c315befd

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Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures

Autor: Giuseppe Locatelli, Nicholas Jonathan Cole King, Claire L. Wishart, Alanna Gabrielle Spiteri

Publikováno v: Wishart, Claire L; Spiteri, Alanna G; Locatelli, Giuseppe; King, Nicholas J C (2023). Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease-specific signatures. GLIA, 71(4), pp. 904-925. Wiley-Blackwell 10.1002/glia.24314

Microglia and bone marrow-derived monocytes are key elements of central nervous system (CNS) inflammation, both capable of enhancing and dampening immune-mediated pathology. However, the study-specific focus on individual cell types, disease models o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebff6184a54d77098dadd621a2be4df
https://boris.unibe.ch/176034/1/Glia_-_2022_-_Wishart_-_Integrating_transcriptomic_datasets_across_neurological_disease_identifies_unique_myeloid.pdf

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Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

Autor: Alanna Gabrielle Spiteri, Claire L. Wishart, Nicholas J. C. King, Giuseppe Locatelli, Roger Pamphlett

Publikováno v: Spiteri, Alanna G; Wishart, Claire L; Pamphlett, Roger; Locatelli, Giuseppe; King, Nicholas J C (2022). Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function. Acta neuropathologica, 143(2), pp. 179-224. Springer-Verlag 10.1007/s00401-021-02384-2
Acta Neuropathologica

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive immune-mediated pathology. However, defining the precise roles of each ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95f12b1edacd502868a5c3ad160bf0e
https://doi.org/10.1007/s00401-021-02384-2

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