Zobrazeno 1 - 10
of 108
pro vyhledávání: '"L, Tooke"'
Autor:
Agata Butryn, Philipp S. Simon, Pierre Aller, Philip Hinchliffe, Ramzi N. Massad, Gabriel Leen, Catherine L. Tooke, Isabel Bogacz, In-Sik Kim, Asmit Bhowmick, Aaron S. Brewster, Nicholas E. Devenish, Jürgen Brem, Jos J. A. G. Kamps, Pauline A. Lang, Patrick Rabe, Danny Axford, John H. Beale, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L. S. Storm, Tiankun Zhou, Shigeki Owada, Rie Tanaka, Kensuke Tono, Gwyndaf Evans, Robin L. Owen, Frances A. Houle, Nicholas K. Sauter, Christopher J. Schofield, James Spencer, Vittal K. Yachandra, Junko Yano, Jan F. Kern, Allen M. Orville
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Currently many of the time resolved serial femtosecond (SFX) crystallography experiments are done with light driven protein systems, whereas the reaction initiation for non-light triggered enzymes remains a major bottle neck. Here, the authors presen
Externí odkaz:
https://doaj.org/article/55ce2079723b464484f4eed86828b06d
Autor:
Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that di
Externí odkaz:
https://doaj.org/article/b7b931b90cef4f15b5875e2a595d88ff
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Publikováno v:
eLife, Vol 10 (2021)
Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and co
Externí odkaz:
https://doaj.org/article/7aac1beac51a40888c31f6d01e330204
Autor:
Anka Lucic, Tika R. Malla, Karina Calvopiña, Catherine L. Tooke, Jürgen Brem, Michael A. McDonough, James Spencer, Christopher J. Schofield
Publikováno v:
Antibiotics, Vol 11, Iss 3, p 396 (2022)
Carbapenems are important antibacterials and are both substrates and inhibitors of some β-lactamases. We report studies on the reaction of the unusual carbapenem biapenem, with the subclass B1 metallo-β-lactamases VIM-1 and VIM-2 and the class A se
Externí odkaz:
https://doaj.org/article/8730b4a5f64843a4aabb65b739538a10
Publikováno v:
South African Medical Journal, Vol 107, Iss 10, Pp 900-903 (2017)
Background. The Groote Schuur Hospital (GSH) neonatal nursery provides level 3 care for the Metro West Health District in the Western Cape Province of South Africa. Worldwide, very-low-birth-weight (VLBW) neonates delivered in level 3 neonatal units
Externí odkaz:
https://doaj.org/article/b83811f9693a4a1493769dc0ee5da9b3
Autor:
Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
Publikováno v:
Tooke, C L, Hinchliffe, P, Beer, M, Zinovjev, K, Colenso, C K, Schofield, C J, Mulholland, A J & Spencer, J 2023, ' Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase ', Journal of the American Chemical Society, vol. 145, no. 13, pp. 7166-7180 . https://doi.org/10.1021/jacs.2c12123
KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c97774ccd121ac85e5e4f7e2ef074a
https://hdl.handle.net/1983/c1ddb86c-11e5-4b02-9062-d77f3e36a9db
https://hdl.handle.net/1983/c1ddb86c-11e5-4b02-9062-d77f3e36a9db
Akademický článek
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Autor:
Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
KPC-2 (Klebsiella pneumoniaecarbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ef8b8613c4bc3d2d7e2c5e2ca429b5
https://doi.org/10.1101/2022.11.11.516172
https://doi.org/10.1101/2022.11.11.516172
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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