Zobrazeno 1 - 10
of 85
pro vyhledávání: '"L, Shargel"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 4(1)
The metabolism and disposition of the bronchodilator, N-t-butylarterenol (tBA) and its di-p-toluate ester (bitolterol) were compared in the rat. Radioactivity was preferentially retained in lungs of rats compared with heart and blood after iv medicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::898dd88cca7b2f65461bc491dacb9b25
https://pubmed.ncbi.nlm.nih.gov/3403
https://pubmed.ncbi.nlm.nih.gov/3403
Publikováno v:
Pharmaceutical research. 6(12)
Sulfasalazine, 60 mg/kg, was administered orally to groups of rats (n = 4) along with 1, 5, or 10 mg/kg of riboflavin. Plasma and urine were assayed for 5-aminosalicylic acid, acetyl-5-aminosalicylic acid, sulfapyridine, and acetyl-sulfapyridine usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2711340efb36ae785e9d31d957a97ee3
https://pubmed.ncbi.nlm.nih.gov/2576130
https://pubmed.ncbi.nlm.nih.gov/2576130
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 2(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cedb4d6c8f1528ac21893fcd057a987f
https://pubmed.ncbi.nlm.nih.gov/4150999
https://pubmed.ncbi.nlm.nih.gov/4150999
Autor:
N S, Yee, L, Shargel
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 14(5)
This study compared the effect of single equimolar oral doses of cimetidine (100 mg/kg) or ranitidine (139 mg/kg) on rat hepatic mixed function oxidases. Cimetidine significantly (p less than 0.05) increased hexobarbital sleeping time and prolonged a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48e156ba93f63ec04c3afbb7b4ee9507
https://pubmed.ncbi.nlm.nih.gov/2876865
https://pubmed.ncbi.nlm.nih.gov/2876865
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 216(1)
The antiarrhythmic drugs ajmaline and its 17-monochloroacetate ester (MCAA; Rtimos-Elle) were studied in cats. MCAA was less than half as toxic as ajmaline. Non-lethal doses of MCAA decreased blood pressure before heart rate, whereas ajmaline initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c871b51385b13e7f61caf673264fa38a
https://pubmed.ncbi.nlm.nih.gov/1164107
https://pubmed.ncbi.nlm.nih.gov/1164107
Autor:
L, Shargel, S A, Dorrbecker
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 4(1)
The metabolism and disposition of bitolterol, the di-p-toluate ester of N-t-butylarterenol (tBA) was studied in man after a single oral dose and in dog after intraduodenal, iv, or oral administration. The mean (+/- SE) peak plasma radioactivity in ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6b8c8d762da15fa8dbbdfb6baf9e260
https://pubmed.ncbi.nlm.nih.gov/3404
https://pubmed.ncbi.nlm.nih.gov/3404
Autor:
J F, Baker, D, Benziger, B W, Chalecki, S, Clemans, A, Fritz, P E, O'Melia, L, Shargel, J, Edelson
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 243(1)
The metabolism of trilostane, a novel inhibitor of adrenal steroidogenesis, was studied in the rat and monkey. In the rat, a peak blood level, equivalent to 2 microgram/ml of trilostane, was observed following a 25 mg/kg oral dose; excretion was main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::088978255dfc3a990079005b83772c5f
https://pubmed.ncbi.nlm.nih.gov/6770769
https://pubmed.ncbi.nlm.nih.gov/6770769
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