Efficacy and safety of oral semaglutide with flexible dose adjustment versus sitagliptin in type 2 diabetes (PIONEER 7): a multicentre, open-label, randomised, phase 3a trial

Autor: M B Manning, D A Streja, C Keller, C H Chung, P L Beckett, A Özdemir, Y M Cho, I Colin, L J Aronne, Erik Christiansen, Markus Laimer, L Van Gaal, S N Lederman, T M O'Connor, L J Klaff, S Aronoff, S H Baik, A V Murray, Signe O R Wallenstein, N A Godbole, H O Høivik, Dilek Gogas Yavuz, A Golay, G T'Sjoen, B Delgado, I N El Ebrashy, E S Kang, C Wium, Bruce W. Bode, Ramazan Sari, B A Palchick, J Geohas, P R Nicol, M Winnie, N Aladağ, E W Braun, C Vercammen, S A Shelbaya, K Sivalingam, S Gorban de Lapertosa, E Riffer, F G Eliaschewitz, J B Buse, B Schultes, C H Sorli, K-W Lee, Mark Warren, T Pieber, S Stäuble, R Prager, A Mertens, A A Arif, D C Eagerton, A Scheen, I J Kim, J A Seo, S Ong, E Ataoglu, John B. Buse, D Berker, A White, F Helland, J C LaRocque, Young Min Cho, Christin L. Hertz, E M Palace, L H S Canani, M P Finneran, S H A Khalil, H L Gulseth, D Weiss, J Condit, E Fließer-Görzer, L Rista, S Akın, M H M F El Hefnawy, N H Kim, C Issa, S Bilz, H Bays, S Fischli, V Preumont, J Pereles-Ortiz, B Bode, E J Morawski, Aytekin Oguz, J Cooper, Tamer Tetiker, Ann Mertens, G Rudofsky, Thomas R. Pieber, W R Litchfield, J L Gross, D L Weinstein

Publikováno v: The lancet. Diabetesendocrinology. 7(7)

BACKGROUND: Oral semaglutide is the first oral formulation of a glucagon-like peptide-1 (GLP-1) receptor agonist developed for the treatment of type 2 diabetes. We aimed to compare the efficacy and safety of flexible dose adjustments of oral semaglut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e132376f3cbf48c52376523aef27e59f
https://pubmed.ncbi.nlm.nih.gov/31320282

Reproduction rate, milk and wool production of Corriedale and East Friesian×Corriedale F1 ewes grazing on natural pastures

Autor: L. Rosés, R. Kremer, F. Perdigón, G. Barbato, L. Rista

Publikováno v: Small Ruminant Research. 90:27-33

A 5-year survey was undertaken to compare the productivity of crossbred ewes (East Friesian (EF) sires × Corriedale (C) dams), relative to purebred Corriedale ewes in terms of reproduction rate, wool production and quality and milk production. The e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6963df1c544ed1e948b04b5fdefc5cf9
https://doi.org/10.1016/j.smallrumres.2009.12.009

[Untitled]

Autor: O. M. Laudanno, L. Rista, A. Rocaspana, L J Aramberry, J.A. Cesolari, J. Esnarriaga, C. Maglione, G. Piombo, A. Godoy, J S Sambrano

Publikováno v: Digestive Diseases and Sciences. 46:779-784

Five experimental models were developed in different groups of Wistar rats (N = 15) to study selective COX-2-inhibitor NSAIDs such as celecoxib and rofecoxib, as follows: (1) dose-dependent oral Celecoxib and Rofecoxib for 5 days, and 24 hr after ora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf143b09011300aefe7fd08ce690a2c
https://doi.org/10.1023/a:1010748316889

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[Celecoxib vs indomethacin and acute gastric lesions in rats]

Autor: O M, Laudanno, J M, Esnarriaga, J A, Cesolari, C B, Maglione, L J, Aramberry, J S, Sambrano, G, Piombo, L, Rista

Publikováno v: Medicina. 60(2)

In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b3a4c21c793c4e09167bd212ead5c9e
https://pubmed.ncbi.nlm.nih.gov/10962812