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Autor:
G S, Akerman, W H, Tolleson, K L, Brown, L L, Zyzak, E, Mourateva, T S, Engin, A, Basaraba, A L, Coker, K E, Creek, L, Pirisi
Publikováno v:
Cancer research. 61(9)
Epidermal growth factor receptor (EGFR) levels are dramatically increased in human keratinocytes (HKc) immortalized with full-length human papillomavirus type 16 (HPV16) DNA (HKc/HPV16), but increases in EGFR levels actually precede immortalization.
Autor:
David L. Tabb, Mark T. Krahmer, Karen F. Fox, David S. Wunschel, K E Creek, Alvin Fox, J R Yates rd, Richard D. Smith, James J. Walters, L Pirisi
Publikováno v:
Analytical chemistry. 72(17)
ESI (electrospray ionization) MS and tandem mass spectrometry (MS/MS) were used for the analysis of single nucleotide polymorphisms (SNPs) and more complex genetic variations. Double-stranded (ds) PCR products were studied. PCR products of the prolin
Publikováno v:
Advances in experimental medicine and biology. 375
Retinoids (vitamin A and its natural and synthetic derivatives) have shown potential as chemopreventive agents, and diets poor in vitamin A and/or its precursor beta-carotene have been linked to an increased risk of cancer at several sites including
Publikováno v:
Antiviral research. 24(2-3)
Preclinical evaluation of the effectiveness of interferon (IFN) therapy on human papillomaviruses (HPV) has been hampered by the inability to propagate these viruses in cell culture. Nonetheless, interferon is used extensively in the treatment of HPV
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 5(5)
Transfection of individual normal human foreskin keratinocyte (HKc) strains with human papillomavirus type 16 (HPV16) DNA results in the establishment of immortalized cell lines (HKc/HPV16) which, like normal HKc, require epidermal growth factor (EGF
Publikováno v:
Advances in experimental medicine and biology. 354
We have used a model system of normal HKc and HKc immortalized by transfection with HPV16 DNA (HKc/HPV16) to investigate the effect of RA on the growth of HKc/HPV16 and the expression of the HPV16 oncogenes E6 and E7. These studies found that HKc/HPV
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2(3)
Human papillomaviruses (HPVs), particularly types 16, 18, and 33, have recently been suggested as etiological agents for cervical neoplasia. However, few studies have explored this relationship among low-income minority women. This case-control study
Publikováno v:
Cancer research. 53(4)
We previously reported that human keratinocytes (HKc) immortalized by transfection with human papillomavirus type 16 DNA (HKc/HPV16) are more sensitive than normal HKc to growth inhibition by retinoic acid (RA), and that RA treatment of HKc/HPV16 inh
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 3(11)
Similar cellular responses are elicited by retinoic acid (RA) and transforming growth factor beta (TGF-beta). We investigated the ability of RA to modulate the production of TGF-beta in normal human keratinocytes (HKc) and HKc lines immortalized by t