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Autor:
Balazs Dome, Kavita Bisht, Sherrie L. Otterbein, Pier Paolo Pandolfi, Eva Csizmadia, Mailin Li, Leo E. Otterbein, Lisa Vikstrom, Daniel B. Costa, Zsuzsanna Németh, Barbara Wegiel, Alborz Feizi, Brian S. Zuckerbraun, János Fillinger
Publikováno v:
Oncotarget
Nemeth, Z, Csizmadia, E, Vikstrom, L, Li, M, Bisht, K, Feizi, A, Otterbein, S, Zuckerbraun, B, Costa, D B, Pandolfi, P P, Fillinger, J, Döme, B, Otterbein, L E & Wegiel, B 2016, ' Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth ' Oncotarget, vol. 7, no. 17, pp. 23919-32 . DOI: 10.18632/oncotarget.8081
Nemeth, Z, Csizmadia, E, Vikstrom, L, Li, M, Bisht, K, Feizi, A, Otterbein, S, Zuckerbraun, B, Costa, D B, Pandolfi, P P, Fillinger, J, Döme, B, Otterbein, L E & Wegiel, B 2016, ' Alterations of tumor microenvironment by carbon monoxide impedes lung cancer growth ' Oncotarget, vol. 7, no. 17, pp. 23919-32 . DOI: 10.18632/oncotarget.8081
We hypothesized that tumor-associated macrophages (TAMs) are controlled by the diffusible gas carbon monoxide (CO). We demonstrate that induction of apoptosis in lung tumors treated with low doses of CO is associated with increased CD86 expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a405f301ca6c7e61596893535e37df17
https://doi.org/10.18632/oncotarget.8081
https://doi.org/10.18632/oncotarget.8081
Autor:
Jonathan J. Hansen, Sherrie L. Otterbein, Joseph C. Onyiah, Ian M. Carroll, Ronald J. Wong, Nitsan Maharshak, Stephanie Schulz, Hyungjin Sally Ryu, Leo E. Otterbein, Ting Jia Fan, Scott E. Plevy
Publikováno v:
Microbiology and Immunology. 59:452-465
Induction of mammalian heme oxygenase (HO)-1 and exposure of animals to carbon monoxide (CO) ameliorates experimental colitis. When enteric bacteria, including Escherichia coli, are exposed to low iron conditions, they express an HO-like enzyme, chuS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c03c99f4ff11bc149e862867648ea27
https://doi.org/10.1111/1348-0421.12282
https://doi.org/10.1111/1348-0421.12282
Autor:
David Gallo, Lukas Adrian Kromer, Isabel Bento, Ana R. Marques, Gonçalo J. L. Bernardes, Marta Norton De Matos, Sherrie L. Otterbein, Ana S. G. Gonçalves, Nuno Penacho, João Seixas, Ana M. L. Gonçalves, Sandra Rodrigues, Rachel A. Ruggieri, Walter Anton Blättler, Patrícia M. Reis, Leo E. Otterbein, Carlos C. Romão
Publikováno v:
Organometallics. 31:5810-5822
The discovery of the biological effects of carbon monoxide (CO) in recent years strongly suggests that CO could find applications as a therapeutic agent. CO is a highly toxic gas when used at industrial doses, due in part to its binding affinity to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70a24e49d42cb1f06bed0d30b9e74668
https://doi.org/10.1021/om300360c
https://doi.org/10.1021/om300360c
Autor:
Leo E. Otterbein, Sherrie L. Otterbein, Henry E. Fessler, Valerie C. Lowe, Beek Yoke Chin, Augustine M.K. Choi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 272:L268-L275
Hemoglobin (Hb) induces heme oxygenase-1 (HO-1), which catalyzes the breakdown of heme to bilirubin, and ferritin. Rats pretreated with Hb have been shown to survive lethal doses of lipopolysaccharide (LPS; see L. Otterbein, S. L. Sylvester, and A. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5f40b19cd5863a77cee39d3185649c
https://doi.org/10.1152/ajplung.1997.272.2.l268
https://doi.org/10.1152/ajplung.1997.272.2.l268
Autor:
Claire Wicks, Sherrie L. Otterbein, Jawed Alam, Pengfei Gong, Daniel Stewart, Cheri Touchard, Augustine M.K. Choi, Matthew E. Burow, Jen Sie Tou
Publikováno v:
Journal of Biological Chemistry. 275:27694-27702
The mouse heme oxygenase-1 (HO-1) gene, ho-1, contains two inducible enhancers, E1 and E2. Of several cell lines tested, induction of an E1/luciferase fusion construct, pE1-luc, by CdCl(2) is most pronounced in MCF-7 cells. In these cells, E1, but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b540f89cb0b421d8dd6b2ea27976708a
https://doi.org/10.1074/jbc.m004729200
https://doi.org/10.1074/jbc.m004729200
Autor:
Joseph M. Pilewski, James C. Hogg, Sherrie L. Otterbein, Simon C. Watkins, Shizu Hayashi, David G. Peters, Chaojun Li, Wen Ning, Yuanpu P. Di, Frank C. Sciurba, David J. Pinsky, Carol Feghali-Bostwick, Augustine M.K. Choi, Sean Alber, Zhihong Zhou, Naftali Kaminski, Ruiping Song
To better understand the molecular basis of chronic obstructive pulmonary disease (COPD), we used serial analysis of gene expression (SAGE) and microarray analysis to compare the gene expression patterns of lung tissues from COPD and control smokers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130f4a55377b88132c2c720901334554
https://europepmc.org/articles/PMC522001/
https://europepmc.org/articles/PMC522001/
Autor:
Peter K.M. Kim, Leo E. Otterbein, Fang Liu, Sherrie L. Otterbein, Brian S. Zuckerbraun, Timothy R. Billiar, Fritz H. Bach, Augustine M.K. Choi
Publikováno v:
The Journal of Experimental Medicine
Carbon monoxide (CO) and nitric oxide (NO) each have mechanistically unique roles in various inflammatory disorders. Although it is known that CO can induce production of NO and that NO can induce expression of the cytoprotective enzyme heme oxygenas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01af1da06fd5970b0309f11aa35fac86
https://pubmed.ncbi.nlm.nih.gov/14657222
https://pubmed.ncbi.nlm.nih.gov/14657222
Autor:
Colleen Fearns, Fang Liu, Richard J. Ulevitch, R. G. Knickelbein, Leo E. Otterbein, Danielle Morse, Emeka Ifedigbo, Sherrie L. Otterbein, Richard A. Flavell, Augustine M.K. Choi
Publikováno v:
The American journal of pathology. 163(6)
The stress-inducible gene heme oxygenase (HO-1) has previously been shown to provide cytoprotection against oxidative stress. The mechanism(s) by which HO-1 provides this cytoprotection is poorly understood. We demonstrate here that carbon monoxide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa311d57181dd9fa95a1c265e923561b
https://pubmed.ncbi.nlm.nih.gov/14633627
https://pubmed.ncbi.nlm.nih.gov/14633627
Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
Autor:
Richard A. Flavell, Zhihong Zhou, Soeren Erik Pischke, Leo E. Otterbein, Augustine M.K. Choi, Danielle Morse, Torsten Loop, Roger J. Davis, Sherrie L. Otterbein
Publikováno v:
The Journal of biological chemistry. 278(39)
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress and modulates pro-inflammatory cytokines. As the sepsis syndrome results from the release of pro-inflammatory mediators, we postulated that heme oxygenase-1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762b44af0b9506918b2ad0a5f340d893
https://pubmed.ncbi.nlm.nih.gov/12857751
https://pubmed.ncbi.nlm.nih.gov/12857751