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Akademický článek

A preliminary study on the quality and safety of milk in donkeys positive for Toxoplasma gondii

Autor: M. Martini, I. Altomonte, F. Mancianti, S. Nardoni, L. Mugnaini, F. Salari

Publikováno v: Animal, Vol 8, Iss 12, Pp 1996-1998 (2014)

Toxoplasmosis is one of the five parasitic diseases considered as a priority for public health action. The consumption of raw milk products represents a possible risk, in particular for certain categories of people. The aim of this study was to evalu

Externí odkaz: https://doaj.org/article/8c7557b3fe37441ca7e1abce76d7639d

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Sampling protein motion and solvent effect during ligand binding

Autor: Luciana Marinelli, Concettina La Motta, L. Mugnaini, Michele Parrinello, Vittorio Limongelli, Stefania Sartini, Ettore Novellino, Federico Da Settimo, Sandro Cosconati

Publikováno v: Proceedings of the National Academy of Sciences. 109:1467-1472

An exhaustive description of the molecular recognition mechanism between a ligand and its biological target is of great value because it provides the opportunity for an exogenous control of the related process. Very often this aim can be pursued usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11f0d0a9682d2e43ee29eeb1eeb38a2
https://doi.org/10.1073/pnas.1112181108

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Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells

Autor: Teresa Di Desidero, Paola Orlandi, Anna Fioravanti, Bastianina Canu, Concettina La Motta, L. Mugnaini, Guido Bocci, Rita Frati, Paolo Miccoli, Sandro Cosconati, Piero Berti, Stefania Sartini, Romano Danesi, Federico Da Settimo, Alessandro Antonelli

Publikováno v: Biochemical Pharmacology. 81:1309-1316

Aims: To demonstrate the antiproliferative and pro-apoptotic activity of the novel pyrazolopyrimidine derivative multiple tyrosine kinase inhibitor CLM3, alone and in combination with SN-38 (the active metabolite of irinotecan), on endothelial and tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab37a43b2423e2514679078bc5a34c
https://doi.org/10.1016/j.bcp.2011.03.022

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Exploiting the Pyrazolo[3,4-d]pyrimidin-4-one Ring System as a Useful Template To Obtain Potent Adenosine Deaminase Inhibitors

Autor: Concettina La Motta, Mario Del Tacca, Matteo Fornai, Francesca Simorini, Silvia Salerno, Antonio Lavecchia, Ettore Novellino, Sabrina Taliani, Federico Da Settimo, Anna Maria Marini, Corrado Blandizzi, Luca Antonioli, L. Mugnaini, Stefania Sartini

Publikováno v: Journal of Medicinal Chemistry. 52:1681-1692

A number of pyrazolo[3,4-d]pyrimidin-4-ones bearing either alkyl or arylalkyl substituents in position 2 of the nucleus were synthesized and tested for their ability to inhibit adenosine deaminase (ADA) from bovine spleen. The 2-arylalkyl derivatives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a461874e12305dd689a992587a3f94
https://doi.org/10.1021/jm801427r

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Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity

Autor: C. LA MOTTA, S. SARTINI, L. MUGNAINI, F. SIMORINI, S. TALIANI, S. SALERNO, A. M. MARINI, G. PRIMOFIORE, F. DA SETTIMO, LAVECCHIA, ANTONIO, NOVELLINO, ETTORE, M. CANTORE, P. FAILLI, M. CIUFFI

2-Phenyl-pyrido[1,2-a]pyrimidin-4-one derivatives bearing a phenol or a catechol moiety in position 2 were tested as aldose reductase (ALR2) inhibitors and exhibited activity levels in the micromolar/submicromolar range. Introduction of a hydroxy gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da2ed585ca7a72f59c15482e9a7fd3
http://hdl.handle.net/11588/303940

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Treatment of Inoperable Non-small Cell Lung Carcinoma Stage IIIB and IV with Cisplatin, Epidoxorubicin, Vindesine and Lonidamine: A Phase II Study

Autor: L. Portalone, Anna Rita Cruciani, Franco Salvati, N Perrone, Francesco Nunziati, A. Lombardi, Antonio Antilli, V Magliacani, L Mugnaini, Mauro Signora

Publikováno v: Tumori Journal. 85:239-242

Aims and Background The polychemotherapeutic regimen PEV (cisplatin, epidoxorubicin and vindesine) + lonidamine proved to be valid in terms of activity and efficacy in the treatment of patients with advanced, previously untreated non-small cell lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778ab94307205fabc81df1e1a7c225f3
https://doi.org/10.1177/030089169908500405

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Novel N(2)-Substituted Pyrazolo[3,4-d]pyrimidine Adenosine A(3) Receptor Antagonists: Inhibition of A(3)-Mediated Human Glioblastoma Cell Proliferation (dagger)

Autor: Luciana Marinelli, Concettina La Motta, Claudia Martini, Giovanni Greco, Sandro Cosconati, Federico Da Settimo, L. Mugnaini, Simona Daniele, Barbara Cosimelli, Anna Maria Marini, Silvia Salerno, Osele Ciampi, Francesca Simorini, Maria Letizia Trincavelli, Sabrina Taliani, Vittorio Limongelli, Ettore Novellino

Adenosine induces glioma cell proliferation by means of an antiapoptotic effect, which is blocked by cotreatment with selective A(3) AR antagonists. In this study, a novel series of N(2)-substituted pyrazolo[3,4-d]pyrimidines 2a-u was developed as hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb72f4d7d2e6e541f6d382d4ef56c07
http://hdl.handle.net/11568/141626

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Inhibition of adenosine deaminase attenuates inflammation in experimental colitis

Autor: Concettina La Motta, Emiliano Duranti, L. Mugnaini, Matteo Fornai, Mario Del Taca, Agostino Virdis, Olga Kastsiuchenka, Gianfranco Natale, Luca Antonioli, Maria Cristina Breschi, Federico Da Settimo, Narcisa Ghisu, Corrado Blandizzi, Rocchina Colucci, Cristina Vassalle

Publikováno v: The Journal of pharmacology and experimental therapeutics. 322(2)

Adenosine modulates the immune system and inhibits inflammation via reduction of cytokine biosynthesis and neutrophil functions. Drugs able to prevent adenosine catabolism could represent an innovative strategy to treat inflammatory bowel disorders.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346158274c6c6a9f5520ed52b6831bd8
https://pubmed.ncbi.nlm.nih.gov/17488880

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Abdominal tuberculosis mimicking Crohn's disease: a difficult diagnosis. Report of a case

Autor: A, Petroianni, L, Mugnaini, G, Laurendi, S, Giousuè, V, Schininà, C, Bibbolino, A, Bisetti

Publikováno v: Panminerva medica. 44(2)

Abdominal involvement by tuberculosis as first site of disease is comparatively rare in industrialized countries. The emergence of new groups of patients at risk arouse a particular and due interest. This report describes a case of abdominal tubercul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::546a36f393cf83e18664f953fcf4b8c4
https://pubmed.ncbi.nlm.nih.gov/12032437

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