Zobrazeno 1 - 10
of 565
pro vyhledávání: '"L, Meeks"'
Autor:
Christoph Königs, Shannon L. Meeks, Beatrice Nolan, Anja Schmidt, Malin Löfqvist, Jennifer Dumont, Lisa Leickt, Sushrusha Nayak, Stefan Lethagen
Publikováno v:
Therapeutic Advances in Hematology, Vol 15 (2024)
Background: Immune tolerance induction (ITI) is the gold standard for inhibitor eradication to restore the clinical efficacy of factor replacement therapy in haemophilia. However, as ITI often requires frequent administration over extended periods, i
Externí odkaz:
https://doaj.org/article/365a3c01fc194e33a031ea202a5cdf0f
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/c46d28289421482983e3bf9f44e14ffd
Autor:
Cameron W. Swanick, MD, Michael H. Shang, PhD, Kevin Erhart, PhD, Jonathan Cabrera, MS, James Burkavage, CMD, Tomas Dvorak, MD, Naren Ramakrishna, MD, PhD, Zhiqiu Li, PhD, Amish Shah, PhD, Sanford L. Meeks, Omar A. Zeidan, PhD, Patrick Kelly, MD, PhD
Publikováno v:
International Journal of Particle Therapy, Vol 10, Iss 2, Pp 85-93 (2023)
Purpose: Many patients with metastatic cancer live years beyond diagnosis, and there remains a need to improve the therapeutic ratio of metastasis-directed radiation for these patients. This study aimed to assess a process for delivering cost-effecti
Externí odkaz:
https://doaj.org/article/7624224130f94b809dad6b0638078270
Autor:
Glaivy Batsuli, Jasmine Ito, Elizabeth S. York, Courtney Cox, Wallace Baldwin, Surinder Gill, Pete Lollar, Shannon L. Meeks
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSoluble antigens complexed with immunoglobulin G (IgG) antibodies can induce robust adaptive immune responses in vitro and in animal models of disease. Factor VIII immune complexes (FVIII-ICs) have been detected in individuals with hemoph
Externí odkaz:
https://doaj.org/article/a70c76ed1368497d958ddeddbe725018
Autor:
Omar A. Zeidan, PhD, Ethan Pepmiller, BSc, Twyla Willoughby, PhD, Zhiqiu Li, PhD, James Burkavage, AS, Brian Harper, MSc, Michael Fraser, BSc, Katie Moffatt, MPH, Sanford L. Meeks, PhD, Naren Ramakrishna, MD, PhD
Publikováno v:
International Journal of Particle Therapy, Pp 10-19 (2022)
Purpose: We present an analysis of various operational metrics for a novel compact proton therapy system, including clinical case mix, subsystems utilization, and quality assurance trends in beam delivery parameters over a period of 5 years. Material
Externí odkaz:
https://doaj.org/article/eb9e87fb2f984287999b4609575f937d
Autor:
Mahboob ur Rehman, PhD, Omar A. Zeidan, PhD, Twyla Willoughby, PhD, Sanford L. Meeks, PhD, Patrick Kelly, MD, Kevin Erhart, PhD
Publikováno v:
International Journal of Particle Therapy, Vol 9, Iss 1, Pp 54-63 (2022)
Purpose: To present quantitative dosimetric evaluations of five proton pencil beam spot placement techniques. Materials and Methods: The spot placement techniques that were investigated include two grid-based (rectilinear grid and hexagonal grid, bot
Externí odkaz:
https://doaj.org/article/ff38ee783d69431cb00772544be73478
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 2, Pp 342-348 (2021)
Abstract Background The majority of patients with hemophilia A with inhibitors who undergo immune tolerance induction (ITI) achieve successful tolerance and transition to factor VIII (FVIII) prophylaxis. A portion of these patients have switched to e
Externí odkaz:
https://doaj.org/article/5bda368db56f4089934e4dcb2918bfe6
Autor:
Seema R. Patel, Taran S. Lundgren, Wallace Hunter Baldwin, Courtney Cox, Ernest T. Parker, John F. Healey, Ryan P. Jajosky, Patricia E. Zerra, Cassandra D. Josephson, Christopher B. Doering, Sean R. Stowell, Shannon L. Meeks
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Humoral immunity to factor VIII (FVIII) represents a significant challenge for the treatment of patients with hemophilia A. Current paradigms indicate that neutralizing antibodies against FVIII (inhibitors) occur through a classical CD4 T cell, germi
Externí odkaz:
https://doaj.org/article/470104dc411c45558fc574d5808a9c73
Autor:
Claude Négrier, Johannes Oldenburg, Gili Kenet, Shannon L. Meeks, Jean‐Claude Bordet, Jens Müller, Sandra Le Quellec, Peter L. Turecek, Nikola Tripkovic, Yesim Dargaud
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Background Neutralizing factor VIII (FVIII) antibodies are a major complication in hemophilia A. Antihemophilic factor VIII (recombinant), porcine sequence (rpFVIII; susoctocog alfa; Baxalta US Inc., a Takeda company) has low cross‐reactiv
Externí odkaz:
https://doaj.org/article/91ce143ec06b44f9b2022550f7cfd2c0
Autor:
Patricia E. Zerra, Ernest T. Parker, Wallace Hunter Baldwin, John F. Healey, Seema R. Patel, James W. McCoy, Courtney Cox, Sean R. Stowell, Shannon L. Meeks
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1724 (2022)
The development of anti-drug antibodies represents a significant barrier to the utilization of protein-based therapies for a wide variety of diseases. While the rate of antibody formation can vary depending on the therapeutic employed and the target
Externí odkaz:
https://doaj.org/article/ce4692653e9c4e57872dea79388e30ad